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Fetal and child health - impact on kidney development and long-term risk of hypertension and kidney disease

Fetal and child health - impact on kidney development and long-term risk of hypertension and kidney disease
Fetal and child health - impact on kidney development and long-term risk of hypertension and kidney disease
Developmental programming of non-communicable diseases is now an established paradigm. With respect to hypertension and chronic kidney disease, adverse events experienced in utero can affect development of the fetal kidney and reduce final nephron number. Low birthweight and prematurity are the most consistent clinical surrogates for a low nephron number and are associated with increased risk of hypertension, proteinuria, and kidney disease in later life. Rapid weight gain in childhood or adolescence further compounds these risks. Low birthweight, prematurity, and rapid childhood weight gain should alert clinicians to an individual's lifelong risk of hypertension and kidney disease, prompting education to minimise additional risk factors and ensuring follow-up. Birthweight and prematurity are affected substantially by maternal nutrition and health during pregnancy. Optimisation of maternal health and early childhood nutrition could, therefore, attenuate this programming cycle and reduce the global burden of hypertension and kidney disease in the future.

This is the fourth in a Series of six papers about global kidney disease

0140-6736
273-283
Luyckx, Valerie
97ebaccf-ee5b-4d7c-95c8-99431cefce5f
Bertram, John
a382da4b-f83c-43b1-8a56-dca001f97846
Brenner, Barry
8c994535-a748-4dd3-938e-25bec09b6d12
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Hoy, Wendy
8659c1f7-e46e-4c27-8a21-364306e4f410
Ozanne, Susan
2dacd19d-751c-422d-8bf7-4f6cbed1ec93
Vikse, Bjorn
4ee53581-c136-4418-b357-4a6d357f516d
Luyckx, Valerie
97ebaccf-ee5b-4d7c-95c8-99431cefce5f
Bertram, John
a382da4b-f83c-43b1-8a56-dca001f97846
Brenner, Barry
8c994535-a748-4dd3-938e-25bec09b6d12
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Hoy, Wendy
8659c1f7-e46e-4c27-8a21-364306e4f410
Ozanne, Susan
2dacd19d-751c-422d-8bf7-4f6cbed1ec93
Vikse, Bjorn
4ee53581-c136-4418-b357-4a6d357f516d

Luyckx, Valerie, Bertram, John, Brenner, Barry, Fall, Caroline, Hoy, Wendy, Ozanne, Susan and Vikse, Bjorn (2013) Fetal and child health - impact on kidney development and long-term risk of hypertension and kidney disease. Lancet, 382 (9888), 273-283. (doi:10.1016/S0140-6736(13)60311-6). (PMID:23727166)

Record type: Article

Abstract

Developmental programming of non-communicable diseases is now an established paradigm. With respect to hypertension and chronic kidney disease, adverse events experienced in utero can affect development of the fetal kidney and reduce final nephron number. Low birthweight and prematurity are the most consistent clinical surrogates for a low nephron number and are associated with increased risk of hypertension, proteinuria, and kidney disease in later life. Rapid weight gain in childhood or adolescence further compounds these risks. Low birthweight, prematurity, and rapid childhood weight gain should alert clinicians to an individual's lifelong risk of hypertension and kidney disease, prompting education to minimise additional risk factors and ensuring follow-up. Birthweight and prematurity are affected substantially by maternal nutrition and health during pregnancy. Optimisation of maternal health and early childhood nutrition could, therefore, attenuate this programming cycle and reduce the global burden of hypertension and kidney disease in the future.

This is the fourth in a Series of six papers about global kidney disease

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Published date: July 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 358891
URI: http://eprints.soton.ac.uk/id/eprint/358891
ISSN: 0140-6736
PURE UUID: 34ef6949-e168-4040-91b2-7550721d2538
ORCID for Caroline Fall: ORCID iD orcid.org/0000-0003-4402-5552

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Date deposited: 14 Oct 2013 15:17
Last modified: 28 Oct 2023 01:34

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Contributors

Author: Valerie Luyckx
Author: John Bertram
Author: Barry Brenner
Author: Caroline Fall ORCID iD
Author: Wendy Hoy
Author: Susan Ozanne
Author: Bjorn Vikse

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