Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function
Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function
The assessment of cerebrovascular regulatory mechanisms often requires flexibly controlled and precisely timed changes in arterial blood pressure (ABP) and/or inspired CO2. In this study, a new system for inducing variations in mean ABP was designed, implemented and tested using programmable sequences and programmable controls to induce pressure changes through bilateral thigh cuffs. The system is also integrated with a computer-controlled switch to select air or a CO2/air mixture to be provided via a face mask. Adaptive feedback control of a pressure generator was required to meet stringent specifications for fast changes, and accuracy in timing and pressure levels applied by the thigh cuffs. The implemented system consists of a PC-based signal analysis/control unit, a pressure control unit and a CO2/air control unit. Initial evaluations were carried out to compare the cuff pressure control performances between adaptive and non-adaptive control configurations. Results show that the adaptive control method can reduce the mean error in sustaining target pressure by 99.57 % and reduce the transient time in pressure increases by 45.21 %. The system has proven a highly effective tool in ongoing research on brain blood flow control.
Blood Pressure, Carbon Dioxide, Cerebrovascular Circulation, Equipment Design, Feedback, Homeostasis, Humans, Male, Middle Aged, Thigh, Journal Article, Research Support, Non-U.S. Gov't
709-718
Fan, Lingke
29024168-8284-4e9b-86e5-685e846e92ac
Bush, Glen
ebda29ff-992f-4910-b82a-03a22c4cc66c
Katsogridakis, Emmanuel
863d80d0-d656-453d-98fe-70f2c16aaaf9
Simpson, David M
53674880-f381-4cc9-8505-6a97eeac3c2a
Allen, Robert
956a918f-278c-48ef-8e19-65aa463f199a
Potter, John
fab3e3b2-70bf-4116-a7dd-3a3731b2f134
Birch, Anthony A
755f2236-4c0c-49b5-9884-de4021acd42d
Panerai, Ronney B
7acaf714-a17c-4df2-a1f3-b148c1445517
June 2013
Fan, Lingke
29024168-8284-4e9b-86e5-685e846e92ac
Bush, Glen
ebda29ff-992f-4910-b82a-03a22c4cc66c
Katsogridakis, Emmanuel
863d80d0-d656-453d-98fe-70f2c16aaaf9
Simpson, David M
53674880-f381-4cc9-8505-6a97eeac3c2a
Allen, Robert
956a918f-278c-48ef-8e19-65aa463f199a
Potter, John
fab3e3b2-70bf-4116-a7dd-3a3731b2f134
Birch, Anthony A
755f2236-4c0c-49b5-9884-de4021acd42d
Panerai, Ronney B
7acaf714-a17c-4df2-a1f3-b148c1445517
Fan, Lingke, Bush, Glen, Katsogridakis, Emmanuel, Simpson, David M, Allen, Robert, Potter, John, Birch, Anthony A and Panerai, Ronney B
(2013)
Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function.
Medical and Biological Engineering and Computing, 51 (6), .
(doi:10.1007/s11517-013-1040-y).
Abstract
The assessment of cerebrovascular regulatory mechanisms often requires flexibly controlled and precisely timed changes in arterial blood pressure (ABP) and/or inspired CO2. In this study, a new system for inducing variations in mean ABP was designed, implemented and tested using programmable sequences and programmable controls to induce pressure changes through bilateral thigh cuffs. The system is also integrated with a computer-controlled switch to select air or a CO2/air mixture to be provided via a face mask. Adaptive feedback control of a pressure generator was required to meet stringent specifications for fast changes, and accuracy in timing and pressure levels applied by the thigh cuffs. The implemented system consists of a PC-based signal analysis/control unit, a pressure control unit and a CO2/air control unit. Initial evaluations were carried out to compare the cuff pressure control performances between adaptive and non-adaptive control configurations. Results show that the adaptive control method can reduce the mean error in sustaining target pressure by 99.57 % and reduce the transient time in pressure increases by 45.21 %. The system has proven a highly effective tool in ongoing research on brain blood flow control.
Text
Manuscript for MedBioEngComput_V10.pdf
- Accepted Manuscript
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e-pub ahead of print date: 7 February 2013
Published date: June 2013
Keywords:
Blood Pressure, Carbon Dioxide, Cerebrovascular Circulation, Equipment Design, Feedback, Homeostasis, Humans, Male, Middle Aged, Thigh, Journal Article, Research Support, Non-U.S. Gov't
Organisations:
Signal Processing & Control Grp
Identifiers
Local EPrints ID: 361386
URI: http://eprints.soton.ac.uk/id/eprint/361386
ISSN: 0140-0118
PURE UUID: 079d0ce9-89de-4e29-9bb7-0317ba7d9822
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Date deposited: 23 Jan 2014 12:15
Last modified: 15 Mar 2024 03:14
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Contributors
Author:
Lingke Fan
Author:
Glen Bush
Author:
Emmanuel Katsogridakis
Author:
John Potter
Author:
Anthony A Birch
Author:
Ronney B Panerai
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