A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation


Crescentini, Marco, Thei, Federico, Bennati, Marco, Saha, Shimul C., de Planque, Maurits R.R., Morgan, Hywel and Tartagni, Marco (2014) A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation IEEE Transactions on Biomedical Circuits and Systems, 9, pp. 334-344. (doi:10.1109/TBCAS.2014.2346402). (PMID:25252284).

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Description/Abstract

Lipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1109/TBCAS.2014.2346402
ISSNs: 1932-4545 (print)
Organisations: Nanoelectronics and Nanotechnology
ePrint ID: 363526
Date :
Date Event
24 July 2014Accepted/In Press
19 September 2014Published
Date Deposited: 26 Mar 2014 09:30
Last Modified: 16 Apr 2017 17:03
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/363526

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