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A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation

A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation
A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation
Lipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities.
1932-4545
334-344
Crescentini, Marco
568e8046-74bd-449f-8794-889643147059
Thei, Federico
c5014b97-007e-482d-87ad-1d43162ac2eb
Bennati, Marco
dd4ae84d-21e3-414b-a8c1-c4abbbf12c3e
Saha, Shimul C.
e2c8a09a-21af-4a31-bd25-26945094e03a
de Planque, Maurits R.R.
a1d33d13-f516-44fb-8d2c-c51d18bc21ba
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Tartagni, Marco
665c139f-e76b-49e2-8cf7-199478891464
Crescentini, Marco
568e8046-74bd-449f-8794-889643147059
Thei, Federico
c5014b97-007e-482d-87ad-1d43162ac2eb
Bennati, Marco
dd4ae84d-21e3-414b-a8c1-c4abbbf12c3e
Saha, Shimul C.
e2c8a09a-21af-4a31-bd25-26945094e03a
de Planque, Maurits R.R.
a1d33d13-f516-44fb-8d2c-c51d18bc21ba
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Tartagni, Marco
665c139f-e76b-49e2-8cf7-199478891464

Crescentini, Marco, Thei, Federico, Bennati, Marco, Saha, Shimul C., de Planque, Maurits R.R., Morgan, Hywel and Tartagni, Marco (2014) A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation IEEE Transactions on Biomedical Circuits and Systems, 9, pp. 334-344. (doi:10.1109/TBCAS.2014.2346402). (PMID:25252284).

Record type: Article

Abstract

Lipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities.

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More information

Accepted/In Press date: 24 July 2014
Published date: 19 September 2014
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 363526
URI: http://eprints.soton.ac.uk/id/eprint/363526
ISSN: 1932-4545
PURE UUID: 94485266-8cec-4f02-baca-03705f5017e9
ORCID for Maurits R.R. de Planque: ORCID iD orcid.org/0000-0002-8787-0513
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 26 Mar 2014 09:30
Last modified: 17 Jul 2017 13:57

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Contributors

Author: Marco Crescentini
Author: Federico Thei
Author: Marco Bennati
Author: Shimul C. Saha
Author: Hywel Morgan ORCID iD
Author: Marco Tartagni

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