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A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation

Crescentini, Marco, Thei, Federico, Bennati, Marco, Saha, Shimul C., de Planque, Maurits R.R., Morgan, Hywel and Tartagni, Marco (2014) A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation IEEE Transactions on Biomedical Circuits and Systems, 9, pp. 334-344. (doi:10.1109/TBCAS.2014.2346402). (PMID:25252284).

Record type: Article


Lipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities.

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Accepted/In Press date: 24 July 2014
Published date: 19 September 2014
Organisations: Nanoelectronics and Nanotechnology


Local EPrints ID: 363526
ISSN: 1932-4545
PURE UUID: 94485266-8cec-4f02-baca-03705f5017e9
ORCID for Maurits R.R. de Planque: ORCID iD
ORCID for Hywel Morgan: ORCID iD

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Date deposited: 26 Mar 2014 09:30
Last modified: 17 Jul 2017 13:57

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Author: Marco Crescentini
Author: Federico Thei
Author: Marco Bennati
Author: Shimul C. Saha
Author: Hywel Morgan ORCID iD
Author: Marco Tartagni

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