Maternal dietary glycemic index and glycemic load in early pregnancy are associated with offspring adiposity in childhood: the Southampton Women's Survey
Maternal dietary glycemic index and glycemic load in early pregnancy are associated with offspring adiposity in childhood: the Southampton Women's Survey
Background: Maternal hyperglycemia in pregnancy is associated with greater adiposity in offspring. The glycemic index (GI) and glycemic load (GL) describe the glycemic response to carbohydrate ingestion. However, the influence of maternal dietary GI and GL in pregnancy on childhood adiposity is unknown.
Objective: We examined relations of maternal dietary GI and GL in early and late pregnancy with offspring body composition.
Design: A total of 906 mother-child pairs from the prospective cohort the Southampton Women’s Survey were included. Children underwent dual-energy X-ray absorptiometry measurements of body composition at birth and 4 and 6 y of age. Log-transformed fat mass and lean mass were standardized with a mean (±SD) of 0 ± 1. Maternal dietary GI and GL were assessed at 11 and 34 wk of gestation by using an administered food-frequency questionnaire.
Results: After control for potential confounders, both maternal dietary GI and GL in early pregnancy were positively associated with fat mass at 4 and 6 y of age [fat mass SDs per 10-unit GI increase: β = 0.43 (95% CI: 0.06, 0.80), P = 0.02 at 4 y of age; β = 0.40 (95% CI: 0.10, 0.70), P = 0.01 at 6 y of age; fat mass SDs per 50-unit GL increase: β = 0.43 (95% CI: 0.19, 0.67), P < 0.001 at 4 y of age; β = 0.27 (95% CI: 0.07, 0.47), P = 0.007 at 6 y of age]. In contrast, there were no associations between maternal dietary GI or GL in late pregnancy and offspring fat mass at these ages. Maternal dietary GI and GL were not associated with fat mass at birth or offspring lean mass at any of the ages studied.
Conclusion: Higher maternal dietary GI and GL in early pregnancy are associated with greater adiposity in childhood.
676-683
Okubo, H.
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Crozier, S.R.
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Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
18 June 2014
Okubo, H.
312209e4-0d07-4722-b86c-2d7bd211377f
Crozier, S.R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Okubo, H., Crozier, S.R., Harvey, N.C., Godfrey, K.M., Inskip, H.M., Cooper, C. and Robinson, S.M.
(2014)
Maternal dietary glycemic index and glycemic load in early pregnancy are associated with offspring adiposity in childhood: the Southampton Women's Survey.
American Journal of Clinical Nutrition, 100 (2), .
(doi:10.3945/ajcn.114.084905).
(PMID:24944056)
Abstract
Background: Maternal hyperglycemia in pregnancy is associated with greater adiposity in offspring. The glycemic index (GI) and glycemic load (GL) describe the glycemic response to carbohydrate ingestion. However, the influence of maternal dietary GI and GL in pregnancy on childhood adiposity is unknown.
Objective: We examined relations of maternal dietary GI and GL in early and late pregnancy with offspring body composition.
Design: A total of 906 mother-child pairs from the prospective cohort the Southampton Women’s Survey were included. Children underwent dual-energy X-ray absorptiometry measurements of body composition at birth and 4 and 6 y of age. Log-transformed fat mass and lean mass were standardized with a mean (±SD) of 0 ± 1. Maternal dietary GI and GL were assessed at 11 and 34 wk of gestation by using an administered food-frequency questionnaire.
Results: After control for potential confounders, both maternal dietary GI and GL in early pregnancy were positively associated with fat mass at 4 and 6 y of age [fat mass SDs per 10-unit GI increase: β = 0.43 (95% CI: 0.06, 0.80), P = 0.02 at 4 y of age; β = 0.40 (95% CI: 0.10, 0.70), P = 0.01 at 6 y of age; fat mass SDs per 50-unit GL increase: β = 0.43 (95% CI: 0.19, 0.67), P < 0.001 at 4 y of age; β = 0.27 (95% CI: 0.07, 0.47), P = 0.007 at 6 y of age]. In contrast, there were no associations between maternal dietary GI or GL in late pregnancy and offspring fat mass at these ages. Maternal dietary GI and GL were not associated with fat mass at birth or offspring lean mass at any of the ages studied.
Conclusion: Higher maternal dietary GI and GL in early pregnancy are associated with greater adiposity in childhood.
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e-pub ahead of print date: 18 June 2014
Published date: 18 June 2014
Organisations:
Human Development & Health
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Local EPrints ID: 367538
URI: http://eprints.soton.ac.uk/id/eprint/367538
ISSN: 0002-9165
PURE UUID: 14b36728-ca7d-4582-a0dc-53dc189a9e1d
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Date deposited: 28 Aug 2014 14:22
Last modified: 18 Mar 2024 02:58
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Author:
H. Okubo
Author:
S.M. Robinson
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