Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism
Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism
The synthesis and anion transport properties of a series of transmembrane anion transporters based on an isophthalamide scaffold with phenyl, naphthyl or anthracenyl central rings are reported. Anion transport studies using POPC vesicles, showed that the compounds have Hill coefficients >1. This is indicative of higher order complex formation, evidence that leads us to suggest that the compounds are not functioning solely as mobile carriers but rather that a cooperative transport mechanism is being observed. Fluorescence spectroscopy was used to show that the compounds aggregate in the phospholipid bilayer, which provides evidence that these compounds function as a self-assembled anion-conducting aggregate
Berry, Stuart N.
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Busschaert, Nathalie
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Frankling, Charlotte L.
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Salter, Dale
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Gale, Philip A.
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Berry, Stuart N.
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Busschaert, Nathalie
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Frankling, Charlotte L.
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Salter, Dale
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Gale, Philip A.
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Berry, Stuart N., Busschaert, Nathalie, Frankling, Charlotte L., Salter, Dale and Gale, Philip A.
(2015)
Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism.
Organic & Biomolecular Chemistry.
(doi:10.1039/C4OB02631D).
Abstract
The synthesis and anion transport properties of a series of transmembrane anion transporters based on an isophthalamide scaffold with phenyl, naphthyl or anthracenyl central rings are reported. Anion transport studies using POPC vesicles, showed that the compounds have Hill coefficients >1. This is indicative of higher order complex formation, evidence that leads us to suggest that the compounds are not functioning solely as mobile carriers but rather that a cooperative transport mechanism is being observed. Fluorescence spectroscopy was used to show that the compounds aggregate in the phospholipid bilayer, which provides evidence that these compounds function as a self-assembled anion-conducting aggregate
Text
Isophthalamide paper revised.docx
- Accepted Manuscript
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Accepted/In Press date: 20 January 2015
e-pub ahead of print date: 30 January 2015
Organisations:
Organic Chemistry: Synthesis, Catalysis and Flow
Identifiers
Local EPrints ID: 373930
URI: http://eprints.soton.ac.uk/id/eprint/373930
ISSN: 1477-0520
PURE UUID: 49e54292-324d-44c9-83b3-966a143dd5de
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Date deposited: 03 Feb 2015 13:48
Last modified: 15 Mar 2024 03:06
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Contributors
Author:
Stuart N. Berry
Author:
Nathalie Busschaert
Author:
Charlotte L. Frankling
Author:
Dale Salter
Author:
Philip A. Gale
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