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Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism

Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism
Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism
The synthesis and anion transport properties of a series of transmembrane anion transporters based on an isophthalamide scaffold with phenyl, naphthyl or anthracenyl central rings are reported. Anion transport studies using POPC vesicles, showed that the compounds have Hill coefficients >1. This is indicative of higher order complex formation, evidence that leads us to suggest that the compounds are not functioning solely as mobile carriers but rather that a cooperative transport mechanism is being observed. Fluorescence spectroscopy was used to show that the compounds aggregate in the phospholipid bilayer, which provides evidence that these compounds function as a self-assembled anion-conducting aggregate
1477-0520
Berry, Stuart N.
c7287fbf-5845-4f28-b3ab-bf3a35e3fd9f
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Frankling, Charlotte L.
f6fb1866-9a3e-4451-bd58-54fc12295feb
Salter, Dale
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Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943
Berry, Stuart N.
c7287fbf-5845-4f28-b3ab-bf3a35e3fd9f
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Frankling, Charlotte L.
f6fb1866-9a3e-4451-bd58-54fc12295feb
Salter, Dale
0f3c9b1c-df1e-4cf0-aa62-4d1732c458ee
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943

Berry, Stuart N., Busschaert, Nathalie, Frankling, Charlotte L., Salter, Dale and Gale, Philip A. (2015) Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism. Organic & Biomolecular Chemistry. (doi:10.1039/C4OB02631D).

Record type: Article

Abstract

The synthesis and anion transport properties of a series of transmembrane anion transporters based on an isophthalamide scaffold with phenyl, naphthyl or anthracenyl central rings are reported. Anion transport studies using POPC vesicles, showed that the compounds have Hill coefficients >1. This is indicative of higher order complex formation, evidence that leads us to suggest that the compounds are not functioning solely as mobile carriers but rather that a cooperative transport mechanism is being observed. Fluorescence spectroscopy was used to show that the compounds aggregate in the phospholipid bilayer, which provides evidence that these compounds function as a self-assembled anion-conducting aggregate

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Isophthalamide paper revised.docx - Accepted Manuscript
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Accepted/In Press date: 20 January 2015
e-pub ahead of print date: 30 January 2015
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 373930
URI: https://eprints.soton.ac.uk/id/eprint/373930
ISSN: 1477-0520
PURE UUID: 49e54292-324d-44c9-83b3-966a143dd5de
ORCID for Philip A. Gale: ORCID iD orcid.org/0000-0001-9751-4910

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Date deposited: 03 Feb 2015 13:48
Last modified: 20 Jul 2019 01:07

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Contributors

Author: Stuart N. Berry
Author: Nathalie Busschaert
Author: Charlotte L. Frankling
Author: Dale Salter
Author: Philip A. Gale ORCID iD

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