Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation
Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation
Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.
733-741
Bartczak, Dorota
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Muskens, Otto L.
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Nitti, Simone
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Millar, Timothy M.
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Kanaras, Antonios G.
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1 May 2015
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Nitti, Simone
aee69803-b6d1-4bf9-9f7f-84955333cd8d
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Bartczak, Dorota, Muskens, Otto L., Nitti, Simone, Millar, Timothy M. and Kanaras, Antonios G.
(2015)
Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation.
Biomaterials Science, 3 (5), .
(doi:10.1039/C5BM00053J).
Abstract
Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.
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Accepted/In Press date: 13 March 2015
e-pub ahead of print date: 23 March 2015
Published date: 1 May 2015
Organisations:
Quantum, Light & Matter Group, Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 377406
URI: http://eprints.soton.ac.uk/id/eprint/377406
PURE UUID: e06af6f8-f1de-45b6-beee-c4636242daf2
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Date deposited: 11 Jun 2015 14:21
Last modified: 15 Mar 2024 03:34
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Contributors
Author:
Dorota Bartczak
Author:
Simone Nitti
Author:
Timothy M. Millar
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