Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies
Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies
BACKGROUND:
Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited.
SOURCES OF DATA:
We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed.
AREAS OF AGREEMENT, AREAS OF CONTROVERSY:
The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small.
GROWING POINTS, AREAS TIMELY FOR DEVELOPING RESEARCH:
Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.
2, 4, 5-T, 4-D, MCPA, MCPP, cancer, epidemiology
75-94
Jayakody, N.
10a2f245-69a2-4950-a271-abac415199c0
Harris, E.C.
3e4bd946-3f09-45a1-8725-d35e80dd7971
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
June 2015
Jayakody, N.
10a2f245-69a2-4950-a271-abac415199c0
Harris, E.C.
3e4bd946-3f09-45a1-8725-d35e80dd7971
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
Jayakody, N., Harris, E.C. and Coggon, D.
(2015)
Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies.
British Medical Bulletin, 114 (1), .
(doi:10.1093/bmb/ldv008).
(PMID:25790819)
Abstract
BACKGROUND:
Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited.
SOURCES OF DATA:
We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed.
AREAS OF AGREEMENT, AREAS OF CONTROVERSY:
The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small.
GROWING POINTS, AREAS TIMELY FOR DEVELOPING RESEARCH:
Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.
Text
Phenoxy Herbicide paper 060215.docx
- Accepted Manuscript
More information
e-pub ahead of print date: 19 March 2015
Published date: June 2015
Keywords:
2, 4, 5-T, 4-D, MCPA, MCPP, cancer, epidemiology
Organisations:
MRC Life-Course Epidemiology Unit
Identifiers
Local EPrints ID: 379207
URI: http://eprints.soton.ac.uk/id/eprint/379207
ISSN: 0007-1420
PURE UUID: ade48457-24a5-4798-a7f3-204483298a8f
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Date deposited: 21 Jul 2015 14:53
Last modified: 15 Mar 2024 02:52
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Contributors
Author:
N. Jayakody
Author:
E.C. Harris
Author:
D. Coggon
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