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Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies

Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies
Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies
BACKGROUND:

Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited.

SOURCES OF DATA:

We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed.

AREAS OF AGREEMENT, AREAS OF CONTROVERSY:

The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small.

GROWING POINTS, AREAS TIMELY FOR DEVELOPING RESEARCH:

Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.
2, 4, 5-T, 4-D, MCPA, MCPP, cancer, epidemiology
0007-1420
75-94
Jayakody, N.
10a2f245-69a2-4950-a271-abac415199c0
Harris, E.C.
3e4bd946-3f09-45a1-8725-d35e80dd7971
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
Jayakody, N.
10a2f245-69a2-4950-a271-abac415199c0
Harris, E.C.
3e4bd946-3f09-45a1-8725-d35e80dd7971
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3

Jayakody, N., Harris, E.C. and Coggon, D. (2015) Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies. British Medical Bulletin, 114 (1), 75-94. (doi:10.1093/bmb/ldv008). (PMID:25790819)

Record type: Article

Abstract

BACKGROUND:

Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited.

SOURCES OF DATA:

We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed.

AREAS OF AGREEMENT, AREAS OF CONTROVERSY:

The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small.

GROWING POINTS, AREAS TIMELY FOR DEVELOPING RESEARCH:

Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.

Text
Phenoxy Herbicide paper 060215.docx - Accepted Manuscript
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More information

e-pub ahead of print date: 19 March 2015
Published date: June 2015
Keywords: 2, 4, 5-T, 4-D, MCPA, MCPP, cancer, epidemiology
Organisations: MRC Life-Course Epidemiology Unit

Identifiers

Local EPrints ID: 379207
URI: http://eprints.soton.ac.uk/id/eprint/379207
ISSN: 0007-1420
PURE UUID: ade48457-24a5-4798-a7f3-204483298a8f
ORCID for E.C. Harris: ORCID iD orcid.org/0000-0001-8037-566X
ORCID for D. Coggon: ORCID iD orcid.org/0000-0003-1930-3987

Catalogue record

Date deposited: 21 Jul 2015 14:53
Last modified: 23 Jul 2022 01:41

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Contributors

Author: N. Jayakody
Author: E.C. Harris ORCID iD
Author: D. Coggon ORCID iD

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