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Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream

Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream
Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream
In the absence of sufficient cleaning of medical instruments, contamination and infection can result in serious consequences for the health sector and remains a significant unmet challenge. In this paper we describe a novel cleaning system reliant on cavitation action created in a free flowing fluid stream where ultrasonic transmission to a surface, through the stream, is achieved using careful design and control of the device architecture, sound field and the materials employed. Cleaning was achieved with purified water at room temperature, moderate fluid flow rates and without the need for chemical additives or the high power consumption associated with conventional strategies. This study illustrates the potential in harnessing an ultrasonically activated stream to remove biological contamination including brain tissue from surgical stainless steel substrates, S. epidermidis biofilms from glass, and fat/soft tissue matter from bone structures with considerable basic and clinical applications.
University of Southampton
Birkin, Peter
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OFFIN, DOUGLAS
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Vian, Christopher
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Howlin, R.P.
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Dawson, J.I.
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Secker, Thomas
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Herve, Rodolphe
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Stoodley, Paul
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Keevil, Charles
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Leighton, Timothy
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Birkin, Peter
ba466560-f27c-418d-89fc-67ea4f81d0a7
OFFIN, DOUGLAS
ddf221b0-9e71-4ffb-97a0-4f5646672851
Vian, Christopher
c5ca4c67-5a34-475e-b99b-04593f9c6cc9
Howlin, R.P.
832d22df-7fe4-4c6e-9bb8-05afc6af21bc
Dawson, J.I.
fb6e70f3-eec4-484e-9259-8d9d1b0cb169
Secker, Thomas
16b0a878-984f-4272-bfaa-667c7c63023a
Herve, Rodolphe
9baddc65-93cf-4a18-9388-088d60572b06
Stoodley, Paul
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Keevil, Charles
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Leighton, Timothy
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Birkin, Peter, OFFIN, DOUGLAS, Vian, Christopher, Howlin, R.P., Dawson, J.I., Secker, Thomas, Herve, Rodolphe, Stoodley, Paul, Keevil, Charles and Leighton, Timothy (2015) Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream. University of Southampton doi:10.5258/SOTON/379275 [Dataset]

Record type: Dataset

Abstract

In the absence of sufficient cleaning of medical instruments, contamination and infection can result in serious consequences for the health sector and remains a significant unmet challenge. In this paper we describe a novel cleaning system reliant on cavitation action created in a free flowing fluid stream where ultrasonic transmission to a surface, through the stream, is achieved using careful design and control of the device architecture, sound field and the materials employed. Cleaning was achieved with purified water at room temperature, moderate fluid flow rates and without the need for chemical additives or the high power consumption associated with conventional strategies. This study illustrates the potential in harnessing an ultrasonically activated stream to remove biological contamination including brain tissue from surgical stainless steel substrates, S. epidermidis biofilms from glass, and fat/soft tissue matter from bone structures with considerable basic and clinical applications.

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More information

Published date: 2015
Additional Information: This work was supported by the 2011 Royal Society Brian Mercer Award for Innovation and Ultrawave Ltd. for which the authors are extremely grateful.
Organisations: Electrochemistry, Chemistry, Academic, Biomedicine, nCATS Group, Acoustics Group

Identifiers

Local EPrints ID: 379275
URI: http://eprints.soton.ac.uk/id/eprint/379275
PURE UUID: 3cd19c48-c23b-472c-afe9-ef37a6789f48
ORCID for Peter Birkin: ORCID iD orcid.org/0000-0002-6656-4074
ORCID for Thomas Secker: ORCID iD orcid.org/0000-0001-7168-8592
ORCID for Rodolphe Herve: ORCID iD orcid.org/0000-0001-8838-6515
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X
ORCID for Charles Keevil: ORCID iD orcid.org/0000-0003-1917-7706
ORCID for Timothy Leighton: ORCID iD orcid.org/0000-0002-1649-8750

Catalogue record

Date deposited: 23 Sep 2015 10:44
Last modified: 11 Sep 2019 00:36

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Contributors

Creator: Peter Birkin ORCID iD
Creator: DOUGLAS OFFIN
Creator: Christopher Vian
Creator: R.P. Howlin
Creator: J.I. Dawson
Creator: Thomas Secker ORCID iD
Creator: Rodolphe Herve ORCID iD
Creator: Paul Stoodley ORCID iD
Creator: Charles Keevil ORCID iD
Creator: Timothy Leighton ORCID iD

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