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Dataset for Dual-Gate Polysilicon Nanoribbon Biosensors Enable High Sensitivity Detection of Proteins

Dataset for Dual-Gate Polysilicon Nanoribbon Biosensors Enable High Sensitivity Detection of Proteins
Dataset for Dual-Gate Polysilicon Nanoribbon Biosensors Enable High Sensitivity Detection of Proteins
We demonstrate the advantages of dual-gate polysilicon nanoribbon biosensors with a comprehensive evaluation of different measurement schemes for pH and protein sensing. In particular, we compare the detection of voltage and current changes when top- and bottom-gate bias is applied. Measurements of pH show that a large voltage shift of 491 mV/pH is obtained in the subthreshold region when the top-gate is kept at a fixed potential and the bottom-gate is varied (voltage sweep). This is an improvement of 16 times over the 30 mV/pH measured using a top-gate sweep with the bottom-gate at a fixed potential. A similar large voltage shift of 175 mV is obtained when the protein avidin is sensed using a bottom-gate sweep. This is an improvement of 20 times compared with the 8.8 mV achieved from a top-gate sweep. Current measurements using bottom-gate sweeps do not deliver the same signal amplification as when using bottom-gate sweeps to measure voltage shifts. Thus, for detecting a small signal change on protein binding, it is advantageous to employ a double-gate transistor and to measure a voltage shift using a bottom-gate sweep. For top-gate sweeps, the use of a dual-gate transistor enables the current sensitivity to be enhanced by applying a negative bias to the bottom-gate to reduce the carrier concentration in the nanoribbon. For pH measurements, the current sensitivity increases from 65% to 149% and for avidin sensing it increases from 1.4% to 2.5%.
University of Southampton
Zeimpekis-Karakonstantinos, Ioannis
a2c354ec-3891-497c-adac-89b3a5d96af0
Sun, Kai
b7c648a3-7be8-4613-9d4d-1bf937fb487b
HU, CHUNXIAO
4892b566-6809-42a8-8285-1c1e93aac730
Ditshego, Jack Nonofo
12e0ccd8-8b73-47bd-a896-07d0268fb769
Thomas, O
f697ea12-a494-421d-a9af-da3a1fbf59af
De Planque, Maurits
a1d33d13-f516-44fb-8d2c-c51d18bc21ba
Chong, Harold
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Ashburn, Peter
68cef6b7-205b-47aa-9efb-f1f09f5c1038
Zeimpekis-Karakonstantinos, Ioannis
a2c354ec-3891-497c-adac-89b3a5d96af0
Sun, Kai
b7c648a3-7be8-4613-9d4d-1bf937fb487b
HU, CHUNXIAO
4892b566-6809-42a8-8285-1c1e93aac730
Ditshego, Jack Nonofo
12e0ccd8-8b73-47bd-a896-07d0268fb769
Thomas, O
f697ea12-a494-421d-a9af-da3a1fbf59af
De Planque, Maurits
a1d33d13-f516-44fb-8d2c-c51d18bc21ba
Chong, Harold
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Ashburn, Peter
68cef6b7-205b-47aa-9efb-f1f09f5c1038

Zeimpekis-Karakonstantinos, Ioannis, Sun, Kai, HU, CHUNXIAO, Ditshego, Jack Nonofo, Thomas, O, De Planque, Maurits, Chong, Harold, Morgan, Hywel and Ashburn, Peter (2016) Dataset for Dual-Gate Polysilicon Nanoribbon Biosensors Enable High Sensitivity Detection of Proteins. University of Southampton [Dataset]

Record type: Dataset

Abstract

We demonstrate the advantages of dual-gate polysilicon nanoribbon biosensors with a comprehensive evaluation of different measurement schemes for pH and protein sensing. In particular, we compare the detection of voltage and current changes when top- and bottom-gate bias is applied. Measurements of pH show that a large voltage shift of 491 mV/pH is obtained in the subthreshold region when the top-gate is kept at a fixed potential and the bottom-gate is varied (voltage sweep). This is an improvement of 16 times over the 30 mV/pH measured using a top-gate sweep with the bottom-gate at a fixed potential. A similar large voltage shift of 175 mV is obtained when the protein avidin is sensed using a bottom-gate sweep. This is an improvement of 20 times compared with the 8.8 mV achieved from a top-gate sweep. Current measurements using bottom-gate sweeps do not deliver the same signal amplification as when using bottom-gate sweeps to measure voltage shifts. Thus, for detecting a small signal change on protein binding, it is advantageous to employ a double-gate transistor and to measure a voltage shift using a bottom-gate sweep. For top-gate sweeps, the use of a dual-gate transistor enables the current sensitivity to be enhanced by applying a negative bias to the bottom-gate to reduce the carrier concentration in the nanoribbon. For pH measurements, the current sensitivity increases from 65% to 149% and for avidin sensing it increases from 1.4% to 2.5%.

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More information

Published date: 8 March 2016
Organisations: ORC Research, Nanoelectronics and Nanotechnology, EEE, Electronics & Computer Science

Identifiers

Local EPrints ID: 379790
URI: https://eprints.soton.ac.uk/id/eprint/379790
PURE UUID: d6f262d7-afb8-4eb9-9d42-c611edddf0ea
ORCID for Maurits De Planque: ORCID iD orcid.org/0000-0002-8787-0513
ORCID for Harold Chong: ORCID iD orcid.org/0000-0002-7110-5761
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 30 Jul 2015 13:42
Last modified: 06 Jun 2018 12:45

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Contributors

Creator: Ioannis Zeimpekis-Karakonstantinos
Creator: Kai Sun
Creator: CHUNXIAO HU
Creator: Jack Nonofo Ditshego
Creator: O Thomas
Creator: Harold Chong ORCID iD
Creator: Hywel Morgan ORCID iD
Creator: Peter Ashburn

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