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Promotion of periostin expression contributes to the migration of Schwann cells

Promotion of periostin expression contributes to the migration of Schwann cells
Promotion of periostin expression contributes to the migration of Schwann cells
Neuregulin ligands and their ErbB receptors are important for the development of Schwann cells, the glial cells of the peripheral nervous system (PNS). ErbB3 deficiency is characterized by a complete loss of Schwann cells along axons of the peripheral nerves, impaired fasciculation and neuronal cell death. We performed comparative gene expression analysis of dorsal root ganglia (DRG) explant cultures from ErbB3-deficient and wild-type mice in order to identify genes that are involved in Schwann cell development and migration. The extracellular matrix (ECM) gene periostin was found to exhibit the most prominent down regulation in ErbB3-deficient DRG. Expression analysis revealed that the periostin-expressing cell population in the PNS corresponds to Schwann cell precursors and Schwann cells, and is particularly high in migratory Schwann cells. Furthermore, stimulation of Schwann cells with neuregulin-1 (NRG1) or transforming growth factor ? (TGF?-1) resulted in an upregulation of periostin expression. Interestingly, DRG explant cultures of periostin-deficient mice revealed a significant reduction of the number of migrating Schwann cells. These data demonstrate that the expression of periostin is stimulated by ErbB ligand NRG1 and influences the migration of Schwann cell precursors
0021-9533
3345-3355
Sonnenberg-Riethmacher, E.
6da24b56-bcab-43c2-8da3-01c99f274f1d
Miehe, M.
0d3bc2c6-0749-4563-aebf-4762bed26218
Riethmacher, D.
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Sonnenberg-Riethmacher, E.
6da24b56-bcab-43c2-8da3-01c99f274f1d
Miehe, M.
0d3bc2c6-0749-4563-aebf-4762bed26218
Riethmacher, D.
1a0a0c2e-e94d-4d0a-a890-90107a2545bc

Sonnenberg-Riethmacher, E., Miehe, M. and Riethmacher, D. (2015) Promotion of periostin expression contributes to the migration of Schwann cells. Journal of Cell Science, 128 (17), 3345-3355. (doi:10.1242/jcs.174177).

Record type: Article

Abstract

Neuregulin ligands and their ErbB receptors are important for the development of Schwann cells, the glial cells of the peripheral nervous system (PNS). ErbB3 deficiency is characterized by a complete loss of Schwann cells along axons of the peripheral nerves, impaired fasciculation and neuronal cell death. We performed comparative gene expression analysis of dorsal root ganglia (DRG) explant cultures from ErbB3-deficient and wild-type mice in order to identify genes that are involved in Schwann cell development and migration. The extracellular matrix (ECM) gene periostin was found to exhibit the most prominent down regulation in ErbB3-deficient DRG. Expression analysis revealed that the periostin-expressing cell population in the PNS corresponds to Schwann cell precursors and Schwann cells, and is particularly high in migratory Schwann cells. Furthermore, stimulation of Schwann cells with neuregulin-1 (NRG1) or transforming growth factor ? (TGF?-1) resulted in an upregulation of periostin expression. Interestingly, DRG explant cultures of periostin-deficient mice revealed a significant reduction of the number of migrating Schwann cells. These data demonstrate that the expression of periostin is stimulated by ErbB ligand NRG1 and influences the migration of Schwann cell precursors

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Accepted/In Press date: 25 June 2015
e-pub ahead of print date: July 2015
Published date: 1 September 2015
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 381672
URI: http://eprints.soton.ac.uk/id/eprint/381672
ISSN: 0021-9533
PURE UUID: 59f7d2ca-79c9-445b-94e7-5a225c666903
ORCID for D. Riethmacher: ORCID iD orcid.org/0000-0002-4206-5529

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Date deposited: 17 Sep 2015 10:45
Last modified: 15 Mar 2024 03:29

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Contributors

Author: E. Sonnenberg-Riethmacher
Author: M. Miehe
Author: D. Riethmacher ORCID iD

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