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Exercise intervention in people with cancer undergoing adjuvant cancer treatment following surgery: a systematic review

Loughney, L., West, M.A., Kemp, G.J., Grocott, M.P.W. and Jack, S. (2015) Exercise intervention in people with cancer undergoing adjuvant cancer treatment following surgery: a systematic review European Journal of Surgical Oncology, pp. 1-13. (doi:10.1016/j.ejso.2015.08.153). (PMID:26358569).

Record type: Article

Abstract

Background

Remaining physically active during and after cancer treatment is known to improve associated adverse effects, improve overall survival and reduce the probability of relapse. This systematic review addresses the question: is an exercise training programme beneficial in people with cancer undergoing adjuvant cancer treatment following surgery.

Methods

A systematic database search of Embase, Ovid, Medline without Revisions, SPORTDiscus, Web of Science, Cochrane Library and ClinicalTrials.gov for any randomised controlled trials (RCT) or non-RCT addressing the effect of an exercise training programme in those having adjuvant cancer treatment following surgery was conducted.

Results

The database search yielded 6489 candidate abstracts of which 94 references included the required terms. A total of 17 articles were included in this review. Exercise training is safe and feasible in the adjuvant setting and furthermore may improve measures of physical fitness and health related quality of life (HRQoL).

Conclusion

This is the first systematic review on exercise training interventions in people with cancer undergoing adjuvant cancer treatment following surgery. Due to the lack of adequately powered RCTs in this area, it remains unclear whether exercise training in this context improves clinical outcomes other physical fitness and HRQoL. It remains unclear what is the optimal timing of initiation of an exercise programme and what are the best combinations of elements within an exercise training programme to optimise training efficacy. Furthermore, it is unclear if initiating such exercise programmes at cancer diagnosis may have a long-lasting effect on physically activity throughout the subsequent life course.

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More information

Accepted/In Press date: 4 August 2015
e-pub ahead of print date: 29 August 2015
Keywords: cancer, surgery, adjuvant cancer treatment, exercise intervention
Organisations: Cancer Sciences, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 383084
URI: http://eprints.soton.ac.uk/id/eprint/383084
ISSN: 0748-7983
PURE UUID: 4ec5913f-eea2-4845-b133-6f00addbcd50

Catalogue record

Date deposited: 22 Oct 2015 10:40
Last modified: 17 Jul 2017 20:15

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Contributors

Author: L. Loughney
Author: M.A. West
Author: G.J. Kemp
Author: M.P.W. Grocott
Author: S. Jack

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