Recent advances in the pathogenesis and treatment of osteoporosis
Recent advances in the pathogenesis and treatment of osteoporosis
Over recent decades, the perception of osteoporosis has changed from that of an inevitable consequence of ageing, to that of a well characterised and treatable chronic non-communicable disease, with major impacts on individuals, healthcare systems and societies. Characterisation of its pathophysiology from the hierarchical structure of bone and the role of its cell population, development of effective strategies for the identification of those most appropriate for treatment, and an increasing armamentarium of efficacious pharmacological therapies, have underpinned this evolution. Despite this marked progress, individuals who experience a fragility fracture remain under-treated in many areas of the world, and there is substantial need for investment both in secondary and primary prevention globally. In this brief article, we give an overview of the pathogenesis of osteoporosis, and summarise current and future approaches to its assessment and treatment.
osteoporosis, epidemiology, pathophysiology, treatment, risk assessment, dxa
S92-S96
Curtis, E.M.
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Moon, R.J.
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Dennison, E.M.
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Harvey, N.C.
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Cooper, C.
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December 2015
Curtis, E.M.
92beef1b-f012-4398-861c-e1156b2adfee
Moon, R.J.
954fb3ed-9934-4649-886d-f65944985a6b
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Curtis, E.M., Moon, R.J., Dennison, E.M., Harvey, N.C. and Cooper, C.
(2015)
Recent advances in the pathogenesis and treatment of osteoporosis.
Clinical Medicine, 15 (6), .
(doi:10.7861/clinmedicine.15-6-s92).
(PMID:26634690)
Abstract
Over recent decades, the perception of osteoporosis has changed from that of an inevitable consequence of ageing, to that of a well characterised and treatable chronic non-communicable disease, with major impacts on individuals, healthcare systems and societies. Characterisation of its pathophysiology from the hierarchical structure of bone and the role of its cell population, development of effective strategies for the identification of those most appropriate for treatment, and an increasing armamentarium of efficacious pharmacological therapies, have underpinned this evolution. Despite this marked progress, individuals who experience a fragility fracture remain under-treated in many areas of the world, and there is substantial need for investment both in secondary and primary prevention globally. In this brief article, we give an overview of the pathogenesis of osteoporosis, and summarise current and future approaches to its assessment and treatment.
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Recent Advances in the%09Pathogenesis_and Treatment of Osteoporosis 29042015.docx
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e-pub ahead of print date: 1 December 2015
Published date: December 2015
Keywords:
osteoporosis, epidemiology, pathophysiology, treatment, risk assessment, dxa
Organisations:
MRC Life-Course Epidemiology Unit
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Local EPrints ID: 385085
URI: http://eprints.soton.ac.uk/id/eprint/385085
ISSN: 1470-2118
PURE UUID: 9b66596d-3756-4f4e-9dea-6f545376a8f4
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Date deposited: 15 Jan 2016 14:11
Last modified: 18 Mar 2024 02:58
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Author:
E.M. Curtis
Author:
R.J. Moon
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