The University of Southampton
University of Southampton Institutional Repository

Accumulation of risk factors associated with poor bone health in older adults

Accumulation of risk factors associated with poor bone health in older adults
Accumulation of risk factors associated with poor bone health in older adults
Summary: Clustering of factors linked with poor bone health is common in older adults and is associated with lower bone density and increased fracture risk in women.

Purpose: Many factors are associated with bone mineral density, which in turn is strongly linked with risk of fragility fracture. We assessed how commonly clustering of risk factors occurs and related such clustering to bone mineral density in a population of older community-dwelling men and women.

Method: This is a cross-sectional study with 498 men and 498 women aged 59 to 72 years, who were participants in the Hertfordshire Cohort Study, in whom incident fracture was recorded. Physical activity, diet quality, history of prior fracture, family history of fracture, cigarette and alcohol consumption and comorbidities were obtained through baseline questionnaire. Measurements of grip strength and bone mineral density of the lumbar spine and total femur were also taken.

Results: Clustering of risk factors was common, with over 30 % having two or more. In women, a graded association between the number of risk factors and low bone density was seen, and strong relationships were also seen between the number of risk factors and incident fracture; women with three or more risk factors had an adjusted hazard ratio (HR) of incident fracture of 5.98 (1.67, 21.43; p?=?0.006) compared to women with no risk factors; women with two risk factors had an adjusted HR of 2.97 (1.14, 7.74; p?=?0.03) and those with one, 2.28 (0.90, 5.75; p?=?0.08).

Conclusion: Clustering of risk factors for poor bone health is common in community-dwelling older adults and is associated with increased risk of fracture and adverse bone health in women.
clustering, lifestle, bone mineral density, smoking, alcohol
1862-3522
1-7
Zhang, J.
722d2564-f8ae-40f1-b1e1-07896b67a0d8
Jameson, K.
d5fb142d-06af-456e-9016-17497f94e9f2
Aihie Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Robinson, S.
ba591c98-4380-456a-be8a-c452f992b69b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.
ee647287-edb4-4392-8361-e59fd505b1d1
Zhang, J.
722d2564-f8ae-40f1-b1e1-07896b67a0d8
Jameson, K.
d5fb142d-06af-456e-9016-17497f94e9f2
Aihie Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Robinson, S.
ba591c98-4380-456a-be8a-c452f992b69b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.
ee647287-edb4-4392-8361-e59fd505b1d1

Zhang, J., Jameson, K., Aihie Sayer, A., Robinson, S., Cooper, C. and Dennison, E. (2016) Accumulation of risk factors associated with poor bone health in older adults. Archives of Osteoporosis, 11 (3), 1-7. (doi:10.1007/s11657-015-0250-3). (PMID:26693939)

Record type: Article

Abstract

Summary: Clustering of factors linked with poor bone health is common in older adults and is associated with lower bone density and increased fracture risk in women.

Purpose: Many factors are associated with bone mineral density, which in turn is strongly linked with risk of fragility fracture. We assessed how commonly clustering of risk factors occurs and related such clustering to bone mineral density in a population of older community-dwelling men and women.

Method: This is a cross-sectional study with 498 men and 498 women aged 59 to 72 years, who were participants in the Hertfordshire Cohort Study, in whom incident fracture was recorded. Physical activity, diet quality, history of prior fracture, family history of fracture, cigarette and alcohol consumption and comorbidities were obtained through baseline questionnaire. Measurements of grip strength and bone mineral density of the lumbar spine and total femur were also taken.

Results: Clustering of risk factors was common, with over 30 % having two or more. In women, a graded association between the number of risk factors and low bone density was seen, and strong relationships were also seen between the number of risk factors and incident fracture; women with three or more risk factors had an adjusted hazard ratio (HR) of incident fracture of 5.98 (1.67, 21.43; p?=?0.006) compared to women with no risk factors; women with two risk factors had an adjusted HR of 2.97 (1.14, 7.74; p?=?0.03) and those with one, 2.28 (0.90, 5.75; p?=?0.08).

Conclusion: Clustering of risk factors for poor bone health is common in community-dwelling older adults and is associated with increased risk of fracture and adverse bone health in women.

Text
Zhang Clustering paper - final.docx - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (92kB)
Text
art%3A10.1007%2Fs11657-015-0250-3.pdf - Version of Record
Available under License Creative Commons Attribution.
Download (995kB)

More information

Accepted/In Press date: 16 November 2015
e-pub ahead of print date: 21 December 2015
Published date: December 2016
Keywords: clustering, lifestle, bone mineral density, smoking, alcohol
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 387237
URI: http://eprints.soton.ac.uk/id/eprint/387237
ISSN: 1862-3522
PURE UUID: caa7d997-1025-43f5-895d-0d2b5f013823
ORCID for S. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for E. Dennison: ORCID iD orcid.org/0000-0002-3048-4961

Catalogue record

Date deposited: 16 Feb 2016 16:58
Last modified: 18 Feb 2021 16:48

Export record

Altmetrics

Contributors

Author: J. Zhang
Author: K. Jameson
Author: A. Aihie Sayer
Author: S. Robinson ORCID iD
Author: C. Cooper ORCID iD
Author: E. Dennison ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×