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Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium

Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium
Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium
The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.
epidemiology, opthalmology, eye diseases, prevalence, risk factors, europe
0393-2990
1-14
Delcourt, Cécile
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Korobelnik, Jean-François
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Foster, Paul J.
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Mirshahi, Alireza
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Hogg, Ruth E.
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Bretillon, Lionel
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Deak, Gabor
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Grauslund, Jakob
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Creuzot-Garcher, Catherine
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Sahel, José
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Daien, Vincent
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Lehtimäki, Terho
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Hense, Hans-Werner
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Rahi, Jugnoo S.
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Cumberland, Phillippa M.
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Schmitz-Valckenberg, Steffen
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Fauser, Sascha
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Bertelsen, Geir
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Wolf, Sebastian
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Lotery, Andrew
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Chakravarthy, Usha
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Fletcher, Astrid
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Klaver, Caroline C.W.
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Delcourt, Cécile
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Korobelnik, Jean-François
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Foster, Paul J.
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Hammond, Christopher J.
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Peto, Tunde
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Jansonius, Nomdo
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Mirshahi, Alireza
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Hogg, Ruth E.
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Topouzis, Fotis
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Deak, Gabor
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Grauslund, Jakob
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Creuzot-Garcher, Catherine
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Sahel, José
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Daien, Vincent
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Lehtimäki, Terho
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Hense, Hans-Werner
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Prokofyeva, Elena
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Oexle, Konrad
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Rahi, Jugnoo S.
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Cumberland, Phillippa M.
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Schmitz-Valckenberg, Steffen
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Fauser, Sascha
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Bertelsen, Geir
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Hoyng, Carel
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Bergen, Arthur
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Silva, Rufino
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Wolf, Sebastian
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Lotery, Andrew
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Chakravarthy, Usha
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Fletcher, Astrid
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Klaver, Caroline C.W.
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Delcourt, Cécile, Korobelnik, Jean-François, Buitendijk, Gabriëlle H.S., Foster, Paul J., Hammond, Christopher J., Piermarocchi, Stefano, Peto, Tunde, Jansonius, Nomdo, Mirshahi, Alireza, Hogg, Ruth E., Bretillon, Lionel, Topouzis, Fotis, Deak, Gabor, Grauslund, Jakob, Broe, Rebecca, Souied, Eric H., Creuzot-Garcher, Catherine, Sahel, José, Daien, Vincent, Lehtimäki, Terho, Hense, Hans-Werner, Prokofyeva, Elena, Oexle, Konrad, Rahi, Jugnoo S., Cumberland, Phillippa M., Schmitz-Valckenberg, Steffen, Fauser, Sascha, Bertelsen, Geir, Hoyng, Carel, Bergen, Arthur, Silva, Rufino, Wolf, Sebastian, Lotery, Andrew, Chakravarthy, Usha, Fletcher, Astrid and Klaver, Caroline C.W. (2015) Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium. European Journal of Epidemiology, 1-14. (doi:10.1007/s10654-015-0098-2). (PMID:26686680)

Record type: Article

Abstract

The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.

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More information

Accepted/In Press date: 27 October 2015
Published date: 19 December 2015
Keywords: epidemiology, opthalmology, eye diseases, prevalence, risk factors, europe
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 390076
URI: https://eprints.soton.ac.uk/id/eprint/390076
ISSN: 0393-2990
PURE UUID: 5be51f97-0068-47a0-ae55-c4bd8666df0b
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305

Catalogue record

Date deposited: 17 Mar 2016 16:40
Last modified: 31 Jan 2019 01:36

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Contributors

Author: Cécile Delcourt
Author: Jean-François Korobelnik
Author: Gabriëlle H.S. Buitendijk
Author: Paul J. Foster
Author: Christopher J. Hammond
Author: Stefano Piermarocchi
Author: Tunde Peto
Author: Nomdo Jansonius
Author: Alireza Mirshahi
Author: Ruth E. Hogg
Author: Lionel Bretillon
Author: Fotis Topouzis
Author: Gabor Deak
Author: Jakob Grauslund
Author: Rebecca Broe
Author: Eric H. Souied
Author: Catherine Creuzot-Garcher
Author: José Sahel
Author: Vincent Daien
Author: Terho Lehtimäki
Author: Hans-Werner Hense
Author: Elena Prokofyeva
Author: Konrad Oexle
Author: Jugnoo S. Rahi
Author: Phillippa M. Cumberland
Author: Steffen Schmitz-Valckenberg
Author: Sascha Fauser
Author: Geir Bertelsen
Author: Carel Hoyng
Author: Arthur Bergen
Author: Rufino Silva
Author: Sebastian Wolf
Author: Andrew Lotery ORCID iD
Author: Usha Chakravarthy
Author: Astrid Fletcher
Author: Caroline C.W. Klaver

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