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Ethnic differences in bone geometry between White, Black and South Asian men in the UK

Ethnic differences in bone geometry between White, Black and South Asian men in the UK
Ethnic differences in bone geometry between White, Black and South Asian men in the UK
Relatively little is known about the bone health of ethnic groups within the UK and data are largely restricted to women. The aim of this study was to investigate ethnic differences in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), bone geometry and strength in UK men.

White European, Black Afro-Caribbean and South Asian men aged over 40 years were recruited from Greater Manchester, UK. aBMD at the spine, hip, femoral neck and whole body were measured by DXA. Bone geometry, strength and vBMD were measured at the radius and tibia using pQCT at the metaphysis (4%) and diaphysis (50% radius; 38% tibia) sites. Adjustments were made for age, weight and height.

Black men had higher aBMD at the whole body, total hip and femoral neck compared to White and South Asian men independent of body size adjustments, with no differences between the latter two groups. White men had longer hip axis lengths than both Black and South Asian men. There were fewer differences in vBMD but White men had significantly lower cortical vBMD at the tibial diaphysis than Black and South Asian men (p < 0.001). At the tibia and radius diaphysis, Black men had larger bones with thicker cortices and greater bending strength than the other groups. There were fewer differences between White and South Asian men. At the metaphysis, South Asian men had smaller bones (p = 0.02) and lower trabecular vBMD at the tibia (p = 0.003). At the diaphysis, after size-correction, South Asian men had similar sized bones but thinner cortices than White men; measures of strength were not broadly reduced in the South Asian men.

Combining pQCT and DXA measurements has given insight into differences in bone phenotype in men from different ethnic backgrounds. Understanding such differences is important in understanding the aetiology of male osteoporosis
8756-3282
1-18
Zengin, A.
ce76fb4e-7db2-4359-a210-65e716c69d76
Cook, M.J.
6961bf6c-82c6-4cfb-96c4-00daab36a988
Adams, J.E.
a33a47cb-53dd-4f17-aebd-9dfff2485f97
Wu, F.C.W.
3ff06c32-2ea1-4574-ae06-9668afe56a44
O'Neill, T.W.
688d84bf-f76f-4777-a3e1-65c6e5526365
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Zengin, A.
ce76fb4e-7db2-4359-a210-65e716c69d76
Cook, M.J.
6961bf6c-82c6-4cfb-96c4-00daab36a988
Adams, J.E.
a33a47cb-53dd-4f17-aebd-9dfff2485f97
Wu, F.C.W.
3ff06c32-2ea1-4574-ae06-9668afe56a44
O'Neill, T.W.
688d84bf-f76f-4777-a3e1-65c6e5526365
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7

Zengin, A., Cook, M.J., Adams, J.E., Wu, F.C.W., O'Neill, T.W. and Ward, Kathryn (2016) Ethnic differences in bone geometry between White, Black and South Asian men in the UK. Bone, 1-18. (doi:10.1016/j.bone.2016.07.018).

Record type: Article

Abstract

Relatively little is known about the bone health of ethnic groups within the UK and data are largely restricted to women. The aim of this study was to investigate ethnic differences in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), bone geometry and strength in UK men.

White European, Black Afro-Caribbean and South Asian men aged over 40 years were recruited from Greater Manchester, UK. aBMD at the spine, hip, femoral neck and whole body were measured by DXA. Bone geometry, strength and vBMD were measured at the radius and tibia using pQCT at the metaphysis (4%) and diaphysis (50% radius; 38% tibia) sites. Adjustments were made for age, weight and height.

Black men had higher aBMD at the whole body, total hip and femoral neck compared to White and South Asian men independent of body size adjustments, with no differences between the latter two groups. White men had longer hip axis lengths than both Black and South Asian men. There were fewer differences in vBMD but White men had significantly lower cortical vBMD at the tibial diaphysis than Black and South Asian men (p < 0.001). At the tibia and radius diaphysis, Black men had larger bones with thicker cortices and greater bending strength than the other groups. There were fewer differences between White and South Asian men. At the metaphysis, South Asian men had smaller bones (p = 0.02) and lower trabecular vBMD at the tibia (p = 0.003). At the diaphysis, after size-correction, South Asian men had similar sized bones but thinner cortices than White men; measures of strength were not broadly reduced in the South Asian men.

Combining pQCT and DXA measurements has given insight into differences in bone phenotype in men from different ethnic backgrounds. Understanding such differences is important in understanding the aetiology of male osteoporosis

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Accepted/In Press date: 21 July 2016
Published date: 22 July 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 398546
URI: http://eprints.soton.ac.uk/id/eprint/398546
ISSN: 8756-3282
PURE UUID: 70756173-4be5-44fd-aa20-2fb5476ee2d2
ORCID for Kathryn Ward: ORCID iD orcid.org/0000-0001-7034-6750

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Date deposited: 28 Jul 2016 08:06
Last modified: 07 Oct 2020 02:08

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Contributors

Author: A. Zengin
Author: M.J. Cook
Author: J.E. Adams
Author: F.C.W. Wu
Author: T.W. O'Neill
Author: Kathryn Ward ORCID iD

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