The University of Southampton
University of Southampton Institutional Repository

Influence of maternal obesity on the long-term health of offspring

Influence of maternal obesity on the long-term health of offspring
Influence of maternal obesity on the long-term health of offspring
In addition to immediate implications for pregnancy complications, increasing evidence implicates maternal obesity as a major determinant of offspring health during childhood and later adult life. Observational studies provide evidence for effects of maternal obesity on her offspring's risks of obesity, coronary heart disease, stroke, type 2 diabetes, and asthma. Maternal obesity could also lead to poorer cognitive performance and increased risk of neurodevelopmental disorders, including cerebral palsy. Preliminary evidence suggests potential implications for immune and infectious-disease-related outcomes. Insights from experimental studies support causal effects of maternal obesity on offspring outcomes, which are mediated at least partly through changes in epigenetic processes, such as alterations in DNA methylation, and perhaps through alterations in the gut microbiome. Although the offspring of obese women who lose weight before pregnancy have a reduced risk of obesity, few controlled intervention studies have been done in which maternal obesity is reversed and the consequences for offspring have been examined. Because the long-term effects of maternal obesity could have profound public health implications, there is an urgent need for studies on causality, underlying mechanisms, and effective interventions to reverse the epidemic of obesity in women of childbearing age and to mitigate consequences for offspring.
2213-8587
53-64
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Reynolds, R.M.
c58e0f89-329d-4e4e-be3f-3c53b2a847cc
Prescott, S.L.
c7aa7907-5eb4-4189-83bb-76caf8d34291
Nyirenda, M.
cddac324-c50e-4551-87ee-3ae544ee4ee6
Jaddoe, V.W.
06629850-fd37-402a-8d15-c4291e829a3b
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Broekman, B.F.
5d4ecbbb-8de0-44d3-952f-6fdef2ac9c04
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Reynolds, R.M.
c58e0f89-329d-4e4e-be3f-3c53b2a847cc
Prescott, S.L.
c7aa7907-5eb4-4189-83bb-76caf8d34291
Nyirenda, M.
cddac324-c50e-4551-87ee-3ae544ee4ee6
Jaddoe, V.W.
06629850-fd37-402a-8d15-c4291e829a3b
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Broekman, B.F.
5d4ecbbb-8de0-44d3-952f-6fdef2ac9c04

Godfrey, K.M., Reynolds, R.M., Prescott, S.L., Nyirenda, M., Jaddoe, V.W., Eriksson, J.G. and Broekman, B.F. (2017) Influence of maternal obesity on the long-term health of offspring. The Lancet Diabetes & Endocrinology, 5 (1), 53-64. (doi:10.1016/S2213-8587(16)30107-3). (PMID:27743978)

Record type: Article

Abstract

In addition to immediate implications for pregnancy complications, increasing evidence implicates maternal obesity as a major determinant of offspring health during childhood and later adult life. Observational studies provide evidence for effects of maternal obesity on her offspring's risks of obesity, coronary heart disease, stroke, type 2 diabetes, and asthma. Maternal obesity could also lead to poorer cognitive performance and increased risk of neurodevelopmental disorders, including cerebral palsy. Preliminary evidence suggests potential implications for immune and infectious-disease-related outcomes. Insights from experimental studies support causal effects of maternal obesity on offspring outcomes, which are mediated at least partly through changes in epigenetic processes, such as alterations in DNA methylation, and perhaps through alterations in the gut microbiome. Although the offspring of obese women who lose weight before pregnancy have a reduced risk of obesity, few controlled intervention studies have been done in which maternal obesity is reversed and the consequences for offspring have been examined. Because the long-term effects of maternal obesity could have profound public health implications, there is an urgent need for studies on causality, underlying mechanisms, and effective interventions to reverse the epidemic of obesity in women of childbearing age and to mitigate consequences for offspring.

Text
TLDE Maternal obesity offspring consequences chapter Revised FINAL.docx - Accepted Manuscript
Download (144kB)

More information

Accepted/In Press date: 7 October 2016
e-pub ahead of print date: 12 October 2016
Published date: January 2017
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 401803
URI: http://eprints.soton.ac.uk/id/eprint/401803
ISSN: 2213-8587
PURE UUID: 9a35e6e3-24a2-47e0-8629-3caae26f05c7
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 19 Oct 2016 14:26
Last modified: 07 Oct 2020 06:46

Export record

Altmetrics

Contributors

Author: K.M. Godfrey ORCID iD
Author: R.M. Reynolds
Author: S.L. Prescott
Author: M. Nyirenda
Author: V.W. Jaddoe
Author: J.G. Eriksson
Author: B.F. Broekman

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×