The use of incretins and fractures - a meta-analysis on population-based real life data
The use of incretins and fractures - a meta-analysis on population-based real life data
The aim of the present study was to estimate the effect of incretins on fracture risk in the real world situation by meta-analysis of the available population-based cohort data.
Pubmed and Embase were searched for original articles investigating use of incretin agents, and fracture risk up to December 2015. Adjusted results were extracted and results were pooled by use of generic inverse variance methods, assuming a random-effects model.
Neither current dipeptidyl peptidase 4 - inhibitors use, nor current glucagon-like peptide 1 receptor agonists use was associated with a decreased risk of fracture: pooled relative risk [pooled RR (95% CI): 1.02 (0.91 to 1.13) and 1.03 (0.87 to 1.22)], respectively.
This meta-analysis demonstrated that current use of incretin agents, was not associated with decreased fracture risk. Our findings show the value of representative real-world populations, and the risks associated with suggesting benefits for medications on the basis of safety reporting in RCTs.
1-10
Driessen, J.H.M.
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de Vries, F.
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van Onzenoort, H.
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Harvey, N.C.
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Neef, C.
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van den Bergh, J.
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Vestergaard, P.
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Henry, R.M.A.
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Driessen, J.H.M.
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de Vries, F.
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van Onzenoort, H.
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Harvey, N.C.
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Neef, C.
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van den Bergh, J.
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Vestergaard, P.
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Henry, R.M.A.
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Driessen, J.H.M., de Vries, F., van Onzenoort, H., Harvey, N.C., Neef, C., van den Bergh, J., Vestergaard, P. and Henry, R.M.A.
(2016)
The use of incretins and fractures - a meta-analysis on population-based real life data.
British Journal of Clinical Pharmacology, .
(doi:10.1111/bcp.13167).
Abstract
The aim of the present study was to estimate the effect of incretins on fracture risk in the real world situation by meta-analysis of the available population-based cohort data.
Pubmed and Embase were searched for original articles investigating use of incretin agents, and fracture risk up to December 2015. Adjusted results were extracted and results were pooled by use of generic inverse variance methods, assuming a random-effects model.
Neither current dipeptidyl peptidase 4 - inhibitors use, nor current glucagon-like peptide 1 receptor agonists use was associated with a decreased risk of fracture: pooled relative risk [pooled RR (95% CI): 1.02 (0.91 to 1.13) and 1.03 (0.87 to 1.22)], respectively.
This meta-analysis demonstrated that current use of incretin agents, was not associated with decreased fracture risk. Our findings show the value of representative real-world populations, and the risks associated with suggesting benefits for medications on the basis of safety reporting in RCTs.
Text
Short report incretin and fracture_revision_clean.docx
- Accepted Manuscript
More information
Accepted/In Press date: 20 October 2016
e-pub ahead of print date: 25 October 2016
Organisations:
MRC Life-Course Epidemiology Unit
Identifiers
Local EPrints ID: 402017
URI: http://eprints.soton.ac.uk/id/eprint/402017
ISSN: 0306-5251
PURE UUID: 1ee0c8bc-9f73-48ed-a7dc-fb1a66574939
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Date deposited: 26 Oct 2016 13:48
Last modified: 15 Mar 2024 06:00
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Contributors
Author:
J.H.M. Driessen
Author:
F. de Vries
Author:
H. van Onzenoort
Author:
C. Neef
Author:
J. van den Bergh
Author:
P. Vestergaard
Author:
R.M.A. Henry
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