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Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective.

Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective.
Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective.
Introduction: Piscirickettsia salmonis (P. salmonis) is the aetiological bacterium of the contagious disease piscirickettsiosis or salmonid rickettsial septicaemia (SRS) and causes significant economic losses to aquaculture production in Chile. Current strategies to control infection are i) indiscriminate antibiotic use and ii) vaccination with predominantly P. salmonis bacterin vaccines that do not provide acceptable levels of protection against piscirickettsiosis.

Areas covered: This review covers the basic biology of P. salmonis, clinical piscirickettsiosis and disease control, the development of current P. salmonis vaccines, innate and adaptive immunity and a 5-year plan to develop new piscirickettsiosis vaccines.

Expert commentary: Fundamental knowledge is lacking on the complexities of P. salmonis-host interactions, relating to bacterial virulence and host innate and adaptive immune responses, which needs to be addressed. The development of new P. salmonis vaccines needs the application of comprehensive ‘omics’ technologies to identify candidate vaccine antigens capable of stimulating long-lasting protective immune responses.
1476-0584
1-14
Maisey, Kevin
9deff4f4-c830-4335-8839-19d45f9a9d78
Montero, Ruth
bef2bd14-b44b-418b-b05c-e0fb7f645bc7
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Maisey, Kevin
9deff4f4-c830-4335-8839-19d45f9a9d78
Montero, Ruth
bef2bd14-b44b-418b-b05c-e0fb7f645bc7
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078

Maisey, Kevin, Montero, Ruth and Christodoulides, Myron (2016) Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective. Expert Review of Vaccines, 1-14. (doi:10.1080/14760584.2017.1244483). (PMID:27690686)

Record type: Article

Abstract

Introduction: Piscirickettsia salmonis (P. salmonis) is the aetiological bacterium of the contagious disease piscirickettsiosis or salmonid rickettsial septicaemia (SRS) and causes significant economic losses to aquaculture production in Chile. Current strategies to control infection are i) indiscriminate antibiotic use and ii) vaccination with predominantly P. salmonis bacterin vaccines that do not provide acceptable levels of protection against piscirickettsiosis.

Areas covered: This review covers the basic biology of P. salmonis, clinical piscirickettsiosis and disease control, the development of current P. salmonis vaccines, innate and adaptive immunity and a 5-year plan to develop new piscirickettsiosis vaccines.

Expert commentary: Fundamental knowledge is lacking on the complexities of P. salmonis-host interactions, relating to bacterial virulence and host innate and adaptive immune responses, which needs to be addressed. The development of new P. salmonis vaccines needs the application of comprehensive ‘omics’ technologies to identify candidate vaccine antigens capable of stimulating long-lasting protective immune responses.

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More information

Accepted/In Press date: 30 September 2016
e-pub ahead of print date: 3 October 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 403963
URI: http://eprints.soton.ac.uk/id/eprint/403963
ISSN: 1476-0584
PURE UUID: 6e426009-daf2-43ab-9b36-e18993a9a197
ORCID for Myron Christodoulides: ORCID iD orcid.org/0000-0002-9663-4731

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Date deposited: 19 Dec 2016 09:37
Last modified: 18 Feb 2021 16:37

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Contributors

Author: Kevin Maisey
Author: Ruth Montero

University divisions

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