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A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS

A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS
A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS
In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.
1479-6678
617-626
Schwarz, Konstantin
6a7ff403-7f87-4204-bfe7-88846f91b4b3
Singh, Satnam
917d5118-cd5e-46e9-baf1-4ae4bb475988
Parasuraman, Satish
c5169f2c-b05c-42dd-b7c8-6d41d2643a64
Bruce, Maggie
9df81916-411b-4096-a731-43302acd703e
Shepstone, Lee
7ca551e6-b5ca-4984-a5c7-8d6983f23580
Feelisch, Martin
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Minnion, Magdalena
ab23b32b-9f8e-4876-aaf5-99cb6a725a2f
Ahmad, Shakil
56205cc8-6dd9-4287-853b-f8bbe6b118fa
Horowitz, John
75aea564-0d68-4885-80f7-f5a06f53ed3d
Dawson, Dana
5fe72d81-1839-4c4b-93c6-d59d496f327e
Frenneaux, Michael
fddad0f8-14ca-4001-bd9e-a1a4342a594f
Schwarz, Konstantin
6a7ff403-7f87-4204-bfe7-88846f91b4b3
Singh, Satnam
917d5118-cd5e-46e9-baf1-4ae4bb475988
Parasuraman, Satish
c5169f2c-b05c-42dd-b7c8-6d41d2643a64
Bruce, Maggie
9df81916-411b-4096-a731-43302acd703e
Shepstone, Lee
7ca551e6-b5ca-4984-a5c7-8d6983f23580
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Minnion, Magdalena
ab23b32b-9f8e-4876-aaf5-99cb6a725a2f
Ahmad, Shakil
56205cc8-6dd9-4287-853b-f8bbe6b118fa
Horowitz, John
75aea564-0d68-4885-80f7-f5a06f53ed3d
Dawson, Dana
5fe72d81-1839-4c4b-93c6-d59d496f327e
Frenneaux, Michael
fddad0f8-14ca-4001-bd9e-a1a4342a594f

Schwarz, Konstantin, Singh, Satnam, Parasuraman, Satish, Bruce, Maggie, Shepstone, Lee, Feelisch, Martin, Minnion, Magdalena, Ahmad, Shakil, Horowitz, John, Dawson, Dana and Frenneaux, Michael (2016) A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS. Future Cardiology, 12 (6), 617-626. (doi:10.2217/fca-2016-0026).

Record type: Article

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

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Accepted/In Press date: 10 May 2016
e-pub ahead of print date: 12 October 2016
Published date: November 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 404891
URI: https://eprints.soton.ac.uk/id/eprint/404891
ISSN: 1479-6678
PURE UUID: b5ba086c-be0b-488d-833c-a537b48d9e8f
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 24 Jan 2017 15:59
Last modified: 03 Dec 2019 06:22

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Contributors

Author: Konstantin Schwarz
Author: Satnam Singh
Author: Satish Parasuraman
Author: Maggie Bruce
Author: Lee Shepstone
Author: Martin Feelisch ORCID iD
Author: Magdalena Minnion
Author: Shakil Ahmad
Author: John Horowitz
Author: Dana Dawson
Author: Michael Frenneaux

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