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A pulse sequence for singlet to heteronuclear magnetization transfer: S2hM

A pulse sequence for singlet to heteronuclear magnetization transfer: S2hM
A pulse sequence for singlet to heteronuclear magnetization transfer: S2hM
We have recently demonstrated, in the context of para-hydrogen induced polarization (PHIP), the conversion of hyperpolarized proton singlet order into heteronuclear magnetisation can be efficiently achieved via a new sequence named S2hM (Singlet to heteronuclear Magnetisation). In this paper we give a detailed theoretical description, supported by an experimental illustration, of S2hM. Theory and experiments on thermally polarized samples demonstrate the proposed method is robust to frequency offset mismatches and radiofrequency field inhomogeneities. The simple implementation, optimisation and the high conversion efficiency, under various regimes of magnetic equivalence, makes S2hM an excellent candidate for a widespread use, particularly within the PHIP arena.
169-178
Stevanato, Gabriele
13f2e0a2-2ce7-4938-a2ac-274a81196a72
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Bengs, Christian
6d086f95-d3e8-4adc-86a5-6b255aee4dd1
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Stevanato, Gabriele
13f2e0a2-2ce7-4938-a2ac-274a81196a72
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Bengs, Christian
6d086f95-d3e8-4adc-86a5-6b255aee4dd1
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8

Stevanato, Gabriele, Eills, James, Bengs, Christian and Pileio, Giuseppe (2017) A pulse sequence for singlet to heteronuclear magnetization transfer: S2hM. Journal of Magnetic Resonance, 277, 169-178. (doi:10.1016/j.jmr.2017.03.002).

Record type: Article

Abstract

We have recently demonstrated, in the context of para-hydrogen induced polarization (PHIP), the conversion of hyperpolarized proton singlet order into heteronuclear magnetisation can be efficiently achieved via a new sequence named S2hM (Singlet to heteronuclear Magnetisation). In this paper we give a detailed theoretical description, supported by an experimental illustration, of S2hM. Theory and experiments on thermally polarized samples demonstrate the proposed method is robust to frequency offset mismatches and radiofrequency field inhomogeneities. The simple implementation, optimisation and the high conversion efficiency, under various regimes of magnetic equivalence, makes S2hM an excellent candidate for a widespread use, particularly within the PHIP arena.

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1-s2.0-S1090780717300654-main - Accepted Manuscript
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Accepted/In Press date: 3 March 2017
e-pub ahead of print date: 6 March 2017
Published date: April 2017
Organisations: Chemistry, Magnetic Resonance

Identifiers

Local EPrints ID: 406567
URI: http://eprints.soton.ac.uk/id/eprint/406567
PURE UUID: f2d5c34b-5961-454a-90cc-e3b3a12fb692
ORCID for Giuseppe Pileio: ORCID iD orcid.org/0000-0001-9223-3896

Catalogue record

Date deposited: 18 Mar 2017 02:23
Last modified: 18 Feb 2021 17:05

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Contributors

Author: Gabriele Stevanato
Author: James Eills
Author: Christian Bengs
Author: Giuseppe Pileio ORCID iD

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