The relationship of bone properties using high resolution peripheral quantitative computed tomography to radiographic components of hip osteoarthritis
The relationship of bone properties using high resolution peripheral quantitative computed tomography to radiographic components of hip osteoarthritis
Objective: Positive associations between radiographic osteoarthritis (OA) and areal bone mineral density (BMD) have been demonstrated and appear strongest when bony features of OA are considered. To date, these associations have not been assessed using HRpQCT.
Design: A total of 318 participants (170 men and 148 women), aged 72.1–81.4 years from a non-selected cohort, underwent HRpQCT of the distal radius and tibia along with hip radiography. Differences in bone microarchitecture were assessed between those with and without osteophytes, sclerosis or joint space narrowing (JSN) in either hip.
Results: Men with osteophytes alone had significantly higher radial trabecular volumetric BMD (Tb.vBMD) and radial and tibial trabecular thickness (Tb.Th). Men with both sclerosis and osteophytes had significantly higher cortical volumetric BMD (Ct.vBMD) and cortical thickness (Ct.Th) at the distal tibia than those with osteophytes alone (P < 0.05). These relationships were maintained after adjustment for age and Body Mass Index (BMI), and were not replicated in women. Bone microarchitecture did not differ significantly in those with JSN from those without it in men or women.
Conclusions
Our findings suggest higher Tb.vBMD and Tb.Th in men with osteophytosis but higher tibial Ct.vBMD and Ct.Th in men with hip joint sclerosis. These results do however require replication in other cohorts.
1478-1483
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Paccou, J.
1b444e18-74b1-4d69-be7f-49295ae64ffb
Ward, K.A.
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Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Moss, C.
ae96895f-5c4a-49cd-a771-53bbd6f1d5fb
Woolston, J.
fbab502a-c5c2-404f-b1d2-4d17b092a248
Javaid, M.K.
64155236-2ef0-4065-b684-cf723a888117
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
September 2017
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Paccou, J.
1b444e18-74b1-4d69-be7f-49295ae64ffb
Ward, K.A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Moss, C.
ae96895f-5c4a-49cd-a771-53bbd6f1d5fb
Woolston, J.
fbab502a-c5c2-404f-b1d2-4d17b092a248
Javaid, M.K.
64155236-2ef0-4065-b684-cf723a888117
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Edwards, M.H., Paccou, J., Ward, K.A., Jameson, K.A., Moss, C., Woolston, J., Javaid, M.K., Cooper, C. and Dennison, E.M.
(2017)
The relationship of bone properties using high resolution peripheral quantitative computed tomography to radiographic components of hip osteoarthritis.
Osteoarthritis and Cartilage, 25 (9), .
(doi:10.1016/j.joca.2017.03.011).
Abstract
Objective: Positive associations between radiographic osteoarthritis (OA) and areal bone mineral density (BMD) have been demonstrated and appear strongest when bony features of OA are considered. To date, these associations have not been assessed using HRpQCT.
Design: A total of 318 participants (170 men and 148 women), aged 72.1–81.4 years from a non-selected cohort, underwent HRpQCT of the distal radius and tibia along with hip radiography. Differences in bone microarchitecture were assessed between those with and without osteophytes, sclerosis or joint space narrowing (JSN) in either hip.
Results: Men with osteophytes alone had significantly higher radial trabecular volumetric BMD (Tb.vBMD) and radial and tibial trabecular thickness (Tb.Th). Men with both sclerosis and osteophytes had significantly higher cortical volumetric BMD (Ct.vBMD) and cortical thickness (Ct.Th) at the distal tibia than those with osteophytes alone (P < 0.05). These relationships were maintained after adjustment for age and Body Mass Index (BMI), and were not replicated in women. Bone microarchitecture did not differ significantly in those with JSN from those without it in men or women.
Conclusions
Our findings suggest higher Tb.vBMD and Tb.Th in men with osteophytosis but higher tibial Ct.vBMD and Ct.Th in men with hip joint sclerosis. These results do however require replication in other cohorts.
Text
Edwards Hip OA HRpQCT Title page and Abstract Revision 2 accepted 2017
- Accepted Manuscript
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Edwards_Hip_OA_HRpQCT_Main_Text_Revision_2
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Accepted/In Press date: 15 March 2017
e-pub ahead of print date: 20 March 2017
Published date: September 2017
Organisations:
Epidemiology, Medical Research Council, Human Development & Health
Identifiers
Local EPrints ID: 407403
URI: http://eprints.soton.ac.uk/id/eprint/407403
ISSN: 1063-4584
PURE UUID: ed1c8155-3101-43b8-aafa-db6abc924947
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Date deposited: 05 Apr 2017 01:08
Last modified: 18 Mar 2024 05:10
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Contributors
Author:
M.H. Edwards
Author:
J. Paccou
Author:
C. Moss
Author:
J. Woolston
Author:
M.K. Javaid
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