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Profile, effects and toxicity of novel psychoactive substances: A systematic review of quantitative studies

Profile, effects and toxicity of novel psychoactive substances: A systematic review of quantitative studies
Profile, effects and toxicity of novel psychoactive substances: A systematic review of quantitative studies
Objective: To investigate the profile, effects and toxicity of novel psychoactive substances (NPS).

Methods: A systematic literature review was conducted between May 2015 and February 2016 and included 19 databases. Search terms included: ‘novel psychoactive substance(s)’, ‘effect(s)’ and ‘toxicity’ and their synonyms. Studies included were those from any country, in any language and between January 2007 and April 2015. Studies published before 2007 and those regarding the synthesis of NPS were excluded. Data was extracted by evaluating the titles, abstract and full text respectively. Consequently, the extraction yielded 20 studies.

Results: A total of 43 NPS derivatives of eight main pharmacological classes were identified. NPS were mostly used among young adults and adults within the age range of 16-64 years old. Cathinones and synthetic cannabinoids were the most prevalent amongst the aforementioned classes. The main desired effects of NPS use were empathy and increased ability to socialise. Reported toxicity associated with the use of NPS included cardiovascular, neurological and psychoactive adverse reactions.

Conclusions: Despite the unique subjective effects associated with the use of NPS, harmful effects could be severe and/or lethal. Therefore, there is a need to develop research in the area of NPS and promote awareness among healthcare professionals.
Assi, Sulaf
589bed4c-75cb-4c5d-bc0f-6cf9564b22af
Gulyamova, Nargilya
dcee0f3b-0cae-40d5-a9c1-baaad20b9fa0
Ibrahim, Kinda
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Kneller, Paul
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Osselton, David
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Assi, Sulaf, Gulyamova, Nargilya, Ibrahim, Kinda, Kneller, Paul and Osselton, David (2017) Profile, effects and toxicity of novel psychoactive substances: A systematic review of quantitative studies Human Psychopharmacology: Clinical and Experimental (doi:10.1002/hup.2607).

Assi, Sulaf, Gulyamova, Nargilya, Ibrahim, Kinda, Kneller, Paul and Osselton, David (2017) Profile, effects and toxicity of novel psychoactive substances: A systematic review of quantitative studies Human Psychopharmacology: Clinical and Experimental (doi:10.1002/hup.2607).

Record type: Article

Abstract

Objective: To investigate the profile, effects and toxicity of novel psychoactive substances (NPS).

Methods: A systematic literature review was conducted between May 2015 and February 2016 and included 19 databases. Search terms included: ‘novel psychoactive substance(s)’, ‘effect(s)’ and ‘toxicity’ and their synonyms. Studies included were those from any country, in any language and between January 2007 and April 2015. Studies published before 2007 and those regarding the synthesis of NPS were excluded. Data was extracted by evaluating the titles, abstract and full text respectively. Consequently, the extraction yielded 20 studies.

Results: A total of 43 NPS derivatives of eight main pharmacological classes were identified. NPS were mostly used among young adults and adults within the age range of 16-64 years old. Cathinones and synthetic cannabinoids were the most prevalent amongst the aforementioned classes. The main desired effects of NPS use were empathy and increased ability to socialise. Reported toxicity associated with the use of NPS included cardiovascular, neurological and psychoactive adverse reactions.

Conclusions: Despite the unique subjective effects associated with the use of NPS, harmful effects could be severe and/or lethal. Therefore, there is a need to develop research in the area of NPS and promote awareness among healthcare professionals.

Other Manuscript 19 February 2017 - Accepted Manuscript
Restricted to Repository staff only until 27 July 2018.

More information

Accepted/In Press date: 27 April 2017
e-pub ahead of print date: 19 June 2017
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 410916
URI: http://eprints.soton.ac.uk/id/eprint/410916
PURE UUID: b496e1f2-ec38-426d-81a8-605d56e57641

Catalogue record

Date deposited: 09 Jun 2017 16:31
Last modified: 17 Jul 2017 13:35

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Contributors

Author: Sulaf Assi
Author: Nargilya Gulyamova
Author: Kinda Ibrahim
Author: Paul Kneller
Author: David Osselton

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