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Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.
Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.
BACKGROUND:
Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood.

METHODS:
By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973-1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973-2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings.

RESULTS:
Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05-1.24; obesity: OR = 1.42, 95% CI = 1.24-1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04-1.22; obesity: OR = 1.38, 95% CI = 1.21-1.57). The results were similar across sex of the siblings.

CONCLUSIONS:
Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted.
ADHD - HKS - guidelines - European - children
0021-9630
711-718
Chen, Qi
3438f553-0bab-47a1-b34a-2ec919559b86
Kuja-Halkola, Ralf
e8335fa9-f245-49a8-9df4-ef31767cd3e8
Sjölander, Arvid
17483419-ae59-46ef-a587-8623aa008834
Serlachius, Eva
7c1c6b8f-a3ff-4fdd-a846-bff8e5d7efd5
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Faraone, Stephen
19b748ae-7a78-4be2-9c00-695f9e7a97ee
Almqvist, Catarina
2b040b02-78fe-461e-adba-ed60d9f77ea0
Larsson, Henrik
1d1c897c-ad54-4ffc-bf84-46b2a57f5bf4
Chen, Qi
3438f553-0bab-47a1-b34a-2ec919559b86
Kuja-Halkola, Ralf
e8335fa9-f245-49a8-9df4-ef31767cd3e8
Sjölander, Arvid
17483419-ae59-46ef-a587-8623aa008834
Serlachius, Eva
7c1c6b8f-a3ff-4fdd-a846-bff8e5d7efd5
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Faraone, Stephen
19b748ae-7a78-4be2-9c00-695f9e7a97ee
Almqvist, Catarina
2b040b02-78fe-461e-adba-ed60d9f77ea0
Larsson, Henrik
1d1c897c-ad54-4ffc-bf84-46b2a57f5bf4

Chen, Qi, Kuja-Halkola, Ralf, Sjölander, Arvid, Serlachius, Eva, Cortese, Samuele, Faraone, Stephen, Almqvist, Catarina and Larsson, Henrik (2017) Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden. Journal of Child Psychology & Psychiatry, 58 (6), 711-718. (doi:10.1111/jcpp.12686).

Record type: Article

Abstract

BACKGROUND:
Despite meta-analytic evidence for the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity, the mechanisms underlying the association are yet to be fully understood.

METHODS:
By linking multiple Swedish national and regional registers, we identified 472,735 index males born during 1973-1992, with information on body weight and height directly measured before they were conscripted for military service. We further identified 523,237 full siblings born during 1973-2002 for the index males. All individuals were followed up from their third birthday to December 31, 2009 for ADHD diagnosis. Logistic regression models were used to estimate the association between overweight/obesity in index males and ADHD in their full siblings.

RESULTS:
Siblings of index males with overweight/obesity had increased risk for ADHD (overweight: OR = 1.14, 95% CI = 1.05-1.24; obesity: OR = 1.42, 95% CI = 1.24-1.63), compared with siblings of index males with normal weight. The results were adjusted for birth year of the index male and sex of the sibling. After further adjustment for ADHD status of the index male, the familial coaggregation remained significant (overweight: OR = 1.13, 95% CI = 1.04-1.22; obesity: OR = 1.38, 95% CI = 1.21-1.57). The results were similar across sex of the siblings.

CONCLUSIONS:
Attention-deficit/hyperactivity disorder and overweight/obesity share familial risk factors, which are not limited to those causing overweight/obesity through the mediation of ADHD. Future research aiming at identifying family-wide environmental risk factors as well as common pleiotropic genetic variants contributing to both traits is warranted.

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Chen_JCPP_2017 - Accepted Manuscript
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More information

Accepted/In Press date: 6 December 2016
e-pub ahead of print date: 25 January 2017
Published date: 1 June 2017
Keywords: ADHD - HKS - guidelines - European - children
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 412002
URI: https://eprints.soton.ac.uk/id/eprint/412002
ISSN: 0021-9630
PURE UUID: 2e2f7872-d680-43b5-9cde-6fd04d08aa57
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 04 Jul 2017 16:31
Last modified: 11 May 2019 04:01

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Contributors

Author: Qi Chen
Author: Ralf Kuja-Halkola
Author: Arvid Sjölander
Author: Eva Serlachius
Author: Samuele Cortese ORCID iD
Author: Stephen Faraone
Author: Catarina Almqvist
Author: Henrik Larsson

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