Overview of fracture prediction tools
Overview of fracture prediction tools
The characterization of risk factors for fracture that contribute significantly to fracture risk, over and above that provided by the bone mineral density, has stimulated the development of risk assessment tools. The more adequately evaluated tools, all available online, include the FRAX® tool, the Garvan fracture risk calculator and, in the United Kingdom only, QFracture®. Differences in the input variables, output, and model construct give rise to marked differences in the computed risks from each calculator. Reasons for the differences include the derivation of fracture probability (FRAX) rather than incidence (Garvan and QFracture), limited calibration (Garvan), and inappropriate source information (QFracture). These differences need to be taken into account in the evaluation of assessment guidelines.
Kanis, John A.
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Harvey, Nicholas
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Johansson, Helena
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Odén, Anders
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McCloskey, Eugene V.
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Leslie, William D.
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Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Odén, Anders
cc56db15-a8d7-40f3-bd92-59d7a9abbf62
McCloskey, Eugene V.
2f057a16-3d4e-4597-80c7-6ce47f969c78
Leslie, William D.
5b2dd5d6-4569-40a3-a9b1-95152d11e4f1
Kanis, John A., Harvey, Nicholas, Johansson, Helena, Odén, Anders, McCloskey, Eugene V. and Leslie, William D.
(2017)
Overview of fracture prediction tools.
Journal of Clinical Densitometry.
(doi:10.1016/j.jocd.2017.06.013).
Abstract
The characterization of risk factors for fracture that contribute significantly to fracture risk, over and above that provided by the bone mineral density, has stimulated the development of risk assessment tools. The more adequately evaluated tools, all available online, include the FRAX® tool, the Garvan fracture risk calculator and, in the United Kingdom only, QFracture®. Differences in the input variables, output, and model construct give rise to marked differences in the computed risks from each calculator. Reasons for the differences include the derivation of fracture probability (FRAX) rather than incidence (Garvan and QFracture), limited calibration (Garvan), and inappropriate source information (QFracture). These differences need to be taken into account in the evaluation of assessment guidelines.
Text
Ch 18 Comparisons v2
- Accepted Manuscript
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Accepted/In Press date: 14 July 2017
e-pub ahead of print date: 14 July 2017
Identifiers
Local EPrints ID: 413503
URI: http://eprints.soton.ac.uk/id/eprint/413503
ISSN: 1094-6950
PURE UUID: 576ad93c-7962-44bd-af45-d7d74c7a7b4d
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Date deposited: 25 Aug 2017 16:31
Last modified: 16 Mar 2024 05:41
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Contributors
Author:
John A. Kanis
Author:
Helena Johansson
Author:
Anders Odén
Author:
Eugene V. McCloskey
Author:
William D. Leslie
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