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A method of integrating spatial proteomics and protein-protein interaction network data

Squires, Steven, Edward, Ewing, Robert, Prugel-Bennett, Adam and Niranjan, Mahesan (2017) A method of integrating spatial proteomics and protein-protein interaction network data In Lecture Notes in Computer Science. Springer. 9 pp.

Record type: Conference or Workshop Item (Paper)

Abstract

The increase in quantity of spatial proteomics data requires a range of analytical techniques to effectively analyse the data. We provide a method of integrating spatial proteomics data together with protein-protein interaction (PPI) networks to enable the extraction of more information. A strong relationship between spatial proteomics and PPI network data was demonstrated. Then a method of converting the PPI network into vectors using spatial proteomics data was explained which allows the integration of the two datasets. The resulting vectors were tested using machine learning techniques and reasonable predictive accuracy was found.

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More information

Accepted/In Press date: 31 July 2017
Keywords: Bioinformatics, Spatial proteomics, Machine learning

Identifiers

Local EPrints ID: 413521
URI: http://eprints.soton.ac.uk/id/eprint/413521
ISSN: 0302-9743
PURE UUID: a60d41bb-5a00-43b4-9ecc-9bc275feb4d8
ORCID for Steven, Edward Squires: ORCID iD orcid.org/0000-0003-3681-1342
ORCID for Robert Ewing: ORCID iD orcid.org/0000-0001-6510-4001

Catalogue record

Date deposited: 25 Aug 2017 16:31
Last modified: 25 Aug 2017 16:31

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