Cancer as a contagious disease
Cancer as a contagious disease
Contagious cancers are malignant cells that are physically transferred between individuals as a natural allograft, forming new clonal tumours. These cancers are highly unusual, but have emerged in 2 mammalian species, the dog and the Tasmanian devil, as well as 4 species of bivalve. The transfer of malignant cells in mammals should initiate a robust immune response and although invertebrates have a less complex immune system, these species still have mechanisms that should prevent engraftment and protect against cellular parasitism. Here the naturally occurring contagious cancers are reviewed to determine what features are important and necessary for the emergence and spread of these types of cancer, with a focus on the mammalian contagious cancers and how they successfully cross histocompatibility barriers.
209-214
Siddle, H.V.
2f0c1307-55d3-4965-a8b0-495c4a799f27
1 April 2017
Siddle, H.V.
2f0c1307-55d3-4965-a8b0-495c4a799f27
Abstract
Contagious cancers are malignant cells that are physically transferred between individuals as a natural allograft, forming new clonal tumours. These cancers are highly unusual, but have emerged in 2 mammalian species, the dog and the Tasmanian devil, as well as 4 species of bivalve. The transfer of malignant cells in mammals should initiate a robust immune response and although invertebrates have a less complex immune system, these species still have mechanisms that should prevent engraftment and protect against cellular parasitism. Here the naturally occurring contagious cancers are reviewed to determine what features are important and necessary for the emergence and spread of these types of cancer, with a focus on the mammalian contagious cancers and how they successfully cross histocompatibility barriers.
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Accepted/In Press date: 20 January 2017
e-pub ahead of print date: 15 February 2017
Published date: 1 April 2017
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Local EPrints ID: 413550
URI: http://eprints.soton.ac.uk/id/eprint/413550
ISSN: 2059-2310
PURE UUID: 812be62f-d5d7-4daf-a491-ac7b85a45ddf
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Date deposited: 25 Aug 2017 16:31
Last modified: 16 Mar 2024 05:14
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