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Characterization approach on the extrusion process of bioceramics for the 3D printing of bone tissue engineering scaffolds

Characterization approach on the extrusion process of bioceramics for the 3D printing of bone tissue engineering scaffolds
Characterization approach on the extrusion process of bioceramics for the 3D printing of bone tissue engineering scaffolds
The present study proposes a characterization approach for the extrusion process of hydroxyapatite (HA) paste considering the nonlinear characteristics of bioceramics materials with the aim of printing high-resolution ceramic scaffolds using low-temperature extrusion 3D printing technology. A novel method named the three-point experimental extrapolation was executed to analyze the necessary extrusion pressure in relation to the extrusion velocity. This new approach presented a higher analytical accuracy as compared to previous methods. The optimum layout of the 3D printer was obtained by the comparative analysis of four typical topological constructions. On this basis, three main factors affecting the extrusion pressure of bioceramics materials, namely paste formulation (solvent content), nozzle length-to-diameter ratio, and the extrusion velocity, were selected as the control factors, and a series of experiments were performed using the L27 (313) orthogonal array. The results indicate that all the control factors significantly affected the extrusion pressure, of which the length-to-diameter ratio of nozzle exhibited the greatest effect. The scaffold printed using low-temperature extrusion 3D printing technology exhibited a uniform microstructure following the optimization of the printing parameters, which validated the ability of the process to accurately control the microstructure. The results of the study can be considered as a guide for the 3D printing of high-resolution bone tissue engineering scaffolds and can be employed to further compression mold bioactive polyetheretherketone/hydroxyapatite (PEEK/HA) composites.
low temperature extrusion, 3D printing, characterization, bioceramics, scaffolds, three-point experimental extrapolation
13860-13868
Zhong, Gaoyan
4122f394-9978-4435-874b-5e8356d19a31
Vaezi, Mohammad
828e14c1-3236-4153-8f69-3837233f48ed
Liu, Ping
15f3c7f6-963d-4b43-82b2-cedad3699910
Pan, Lin
816bd8e2-c752-4066-bb12-9e9f7025b669
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1
Zhong, Gaoyan
4122f394-9978-4435-874b-5e8356d19a31
Vaezi, Mohammad
828e14c1-3236-4153-8f69-3837233f48ed
Liu, Ping
15f3c7f6-963d-4b43-82b2-cedad3699910
Pan, Lin
816bd8e2-c752-4066-bb12-9e9f7025b669
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1

Zhong, Gaoyan, Vaezi, Mohammad, Liu, Ping, Pan, Lin and Yang, Shoufeng (2017) Characterization approach on the extrusion process of bioceramics for the 3D printing of bone tissue engineering scaffolds. Ceramics International, 43 (16), 13860-13868. (doi:10.1016/j.ceramint.2017.07.109).

Record type: Article

Abstract

The present study proposes a characterization approach for the extrusion process of hydroxyapatite (HA) paste considering the nonlinear characteristics of bioceramics materials with the aim of printing high-resolution ceramic scaffolds using low-temperature extrusion 3D printing technology. A novel method named the three-point experimental extrapolation was executed to analyze the necessary extrusion pressure in relation to the extrusion velocity. This new approach presented a higher analytical accuracy as compared to previous methods. The optimum layout of the 3D printer was obtained by the comparative analysis of four typical topological constructions. On this basis, three main factors affecting the extrusion pressure of bioceramics materials, namely paste formulation (solvent content), nozzle length-to-diameter ratio, and the extrusion velocity, were selected as the control factors, and a series of experiments were performed using the L27 (313) orthogonal array. The results indicate that all the control factors significantly affected the extrusion pressure, of which the length-to-diameter ratio of nozzle exhibited the greatest effect. The scaffold printed using low-temperature extrusion 3D printing technology exhibited a uniform microstructure following the optimization of the printing parameters, which validated the ability of the process to accurately control the microstructure. The results of the study can be considered as a guide for the 3D printing of high-resolution bone tissue engineering scaffolds and can be employed to further compression mold bioactive polyetheretherketone/hydroxyapatite (PEEK/HA) composites.

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More information

Accepted/In Press date: 13 July 2017
e-pub ahead of print date: 16 July 2017
Published date: November 2017
Keywords: low temperature extrusion, 3D printing, characterization, bioceramics, scaffolds, three-point experimental extrapolation

Identifiers

Local EPrints ID: 413805
URI: http://eprints.soton.ac.uk/id/eprint/413805
PURE UUID: 5619bb97-29a4-4044-a5ae-c27972c3022b
ORCID for Shoufeng Yang: ORCID iD orcid.org/0000-0002-3888-3211

Catalogue record

Date deposited: 06 Sep 2017 16:31
Last modified: 07 Oct 2020 04:43

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