B cells promote pancreatic tumorigenesis
B cells promote pancreatic tumorigenesis
Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor-immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies.
B-Lymphocytes, Carcinoma, Pancreatic Ductal, Cell Transformation, Neoplastic, Disease Progression, Humans, Pancreas, Comment, Journal Article, Research Support, Non-U.S. Gov't
230-232
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Fraser, Christopher
c6722402-4c3a-4156-93ce-a51a3388ffa8
Kleyman, Marianna
f4a1a924-ebc9-481e-8f3b-a4ec06f8be44
Chen, Jianzhu
3cdf9960-ff91-4cad-8b71-2b0dafe11c4d
March 2016
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Fraser, Christopher
c6722402-4c3a-4156-93ce-a51a3388ffa8
Kleyman, Marianna
f4a1a924-ebc9-481e-8f3b-a4ec06f8be44
Chen, Jianzhu
3cdf9960-ff91-4cad-8b71-2b0dafe11c4d
Roghanian, Ali, Fraser, Christopher, Kleyman, Marianna and Chen, Jianzhu
(2016)
B cells promote pancreatic tumorigenesis.
Cancer Discovery, 6 (3), .
(doi:10.1158/2159-8290.CD-16-0100).
Abstract
Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor-immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies.
Text
IntheSpotlight-Cancer Disc. (Jan 16)
- Accepted Manuscript
More information
e-pub ahead of print date: 6 March 2016
Published date: March 2016
Keywords:
B-Lymphocytes, Carcinoma, Pancreatic Ductal, Cell Transformation, Neoplastic, Disease Progression, Humans, Pancreas, Comment, Journal Article, Research Support, Non-U.S. Gov't
Identifiers
Local EPrints ID: 414056
URI: http://eprints.soton.ac.uk/id/eprint/414056
ISSN: 2159-8274
PURE UUID: 1da5945f-fd5c-49b0-a0fb-b46d59a21790
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Date deposited: 13 Sep 2017 16:31
Last modified: 16 Mar 2024 04:01
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Contributors
Author:
Christopher Fraser
Author:
Marianna Kleyman
Author:
Jianzhu Chen
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