Development and validation of an abbreviated questionnaire to easily measure cognitive failure in ICU survivors: A multicenter study

Abstract

Objectives: to develop and validate an abbreviated version of the Cognitive Failure Questionnaire (CFQ) that can be used by patients as part of self assessment to measure functional cognitive outcome in Intensive Care Unit (ICU) survivors.

Design: a retrospective multicenter observational study.

Setting: the ICUs of two Dutch university hospitals.

Patients: adult ICU survivors.

Interventions: none.

Measurements and main results: ognitive functioning was evaluated between 12 and 24 months after ICU discharge using the full 25 item CFQ (CFQ-25). Incomplete CFQ-25 questionnaires were excluded from analysis.
Forward selection in a linear regression model was used in hospital A, to assess which of the 25 CFQ items should be included to prevent a significant loss of correlation between an abbreviated and the full CFQ-25. Subsequently, the performance of an abbreviated CFQ was determined in hospital B using Pearson’s correlation. A Bland Altman plot was used to examine whether the reduced-item outcome scores of an abbreviated CFQ were a replacement for the full CFQ-25 outcome scores.
Among 1934 ICU survivors 1737 were included, 819 in hospital A, 918 in hospital B. The Pearson’s correlation between the abbreviated 14 item CFQ and the CFQ-25 was 0.99. The mean of the difference scores was -0.26 and 95% of the difference scores fell within +5 and -5.5 on a 100-point maximum score.

Conclusions: it is feasible to use the abbreviated CFQ-14 to measure self-reported cognitive failure in ICU survivors as this questionnaire has a similar performance as the full CFQ-25.

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Identifiers

ORCID for Lisette Schoonhoven: orcid.org/0000-0002-7129-3766

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