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Relationships between markers of inflammation and muscle mass, strength and function: findings from the Hertfordshire Cohort Study

Relationships between markers of inflammation and muscle mass, strength and function: findings from the Hertfordshire Cohort Study
Relationships between markers of inflammation and muscle mass, strength and function: findings from the Hertfordshire Cohort Study
We investigated the longitudinal relationships between inflammation markers and the following outcomes in a UK cohort study: appendicular lean mass (ALM); walking speed; level and change in grip strength; and sarcopenia defined by the European Working Group on Sarcopenia in Older People. Analyses were based on 336 community-dwelling older men and women (aged 59–70 years) who participated in the Hertfordshire Cohort Study (HCS). Inflammation markers were ascertained at baseline using enzyme-linked immunosorbent assay techniques and Bio-Plex Pro Assays. Grip strength was measured at baseline and follow-up [median follow-up time: 10.8 years (inter-quartile range 10.2–11.6)] and change in grip strength was ascertained using a residual change approach. At follow-up, ALM was ascertained using dual-energy X-ray absorptiometry, customary walking speed was measured and sarcopenia status was ascertained. Gender-adjusted linear and Poisson regression was used to examine the associations between inflammation markers and outcomes with and without adjustment for anthropometric and lifestyle factors. Higher C-reactive protein was associated (p < 0.04) with lower grip strength and accelerated decline in grip strength from baseline to follow-up. Higher cortisol was associated with lower ALM (p < 0.05). Higher interleukin-8 (IL-8) was associated with lower ALM (p < 0.05) and increased risk of sarcopenia [fully-adjusted relative risk per SD increase in IL-8: 1.37 (95% CI 1.10, 1.71), p = 0.005]. All associations were robust in fully-adjusted analyses. Inflammation markers were associated with measures of muscle mass, strength and function in HCS. Further work is required to replicate these associations and to delineate the underlying mechanisms.
0171-967X
287–295
Westbury, Leo
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Fuggle, N.R.
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Syddall, Holly Emma
a0181a93-8fc3-4998-a996-7963f0128328
Duggal, N.A.
cb194683-76ab-4c77-93da-b5a3462324a5
Shaw, Sarah
9629b12a-8ee2-4483-a9ca-6efb4eef74c8
Maslin, Kate
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Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Lord, J.M.
99e55233-4712-41f1-9c54-d3e2ad83b17c
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Westbury, Leo
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Fuggle, N.R.
512794d2-cfcb-41ca-b150-8312dba7b54a
Syddall, Holly Emma
a0181a93-8fc3-4998-a996-7963f0128328
Duggal, N.A.
cb194683-76ab-4c77-93da-b5a3462324a5
Shaw, Sarah
9629b12a-8ee2-4483-a9ca-6efb4eef74c8
Maslin, Kate
9d337ccf-5720-46b8-8bd1-fecb2f7ac2d1
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Lord, J.M.
99e55233-4712-41f1-9c54-d3e2ad83b17c
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Westbury, Leo, Fuggle, N.R., Syddall, Holly Emma, Duggal, N.A., Shaw, Sarah, Maslin, Kate, Dennison, Elaine, Lord, J.M. and Cooper, Cyrus (2018) Relationships between markers of inflammation and muscle mass, strength and function: findings from the Hertfordshire Cohort Study. Calcified Tissue International, 2018 (102), 287–295. (doi:10.1007/s00223-017-0354-4).

Record type: Article

Abstract

We investigated the longitudinal relationships between inflammation markers and the following outcomes in a UK cohort study: appendicular lean mass (ALM); walking speed; level and change in grip strength; and sarcopenia defined by the European Working Group on Sarcopenia in Older People. Analyses were based on 336 community-dwelling older men and women (aged 59–70 years) who participated in the Hertfordshire Cohort Study (HCS). Inflammation markers were ascertained at baseline using enzyme-linked immunosorbent assay techniques and Bio-Plex Pro Assays. Grip strength was measured at baseline and follow-up [median follow-up time: 10.8 years (inter-quartile range 10.2–11.6)] and change in grip strength was ascertained using a residual change approach. At follow-up, ALM was ascertained using dual-energy X-ray absorptiometry, customary walking speed was measured and sarcopenia status was ascertained. Gender-adjusted linear and Poisson regression was used to examine the associations between inflammation markers and outcomes with and without adjustment for anthropometric and lifestyle factors. Higher C-reactive protein was associated (p < 0.04) with lower grip strength and accelerated decline in grip strength from baseline to follow-up. Higher cortisol was associated with lower ALM (p < 0.05). Higher interleukin-8 (IL-8) was associated with lower ALM (p < 0.05) and increased risk of sarcopenia [fully-adjusted relative risk per SD increase in IL-8: 1.37 (95% CI 1.10, 1.71), p = 0.005]. All associations were robust in fully-adjusted analyses. Inflammation markers were associated with measures of muscle mass, strength and function in HCS. Further work is required to replicate these associations and to delineate the underlying mechanisms.

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Complete manuscript (Inflammation vs sarcopenia in HCS) - Accepted Manuscript
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Accepted/In Press date: 19 October 2017
e-pub ahead of print date: 3 November 2017
Published date: March 2018

Identifiers

Local EPrints ID: 415622
URI: https://eprints.soton.ac.uk/id/eprint/415622
ISSN: 0171-967X
PURE UUID: f073507a-9f01-4bde-abfa-e6c04dc578b4
ORCID for Holly Emma Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 16 Nov 2017 17:30
Last modified: 03 Dec 2019 02:00

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Contributors

Author: Leo Westbury
Author: N.R. Fuggle
Author: N.A. Duggal
Author: Sarah Shaw
Author: Kate Maslin
Author: Elaine Dennison ORCID iD
Author: J.M. Lord
Author: Cyrus Cooper ORCID iD

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