The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative
The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative
Purpose:
To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database.
Methods:
A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs).
Results:
Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1).
Conclusions:
Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.
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Veronese, Nicola
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Shivappa, Nitin
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Stubbs, Brendon
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Smith, Toby
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Hebert, Jame R.
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Cooper, Cyrus
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Guglielmi, Giuseppe
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Reginster, Jean-Yves
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Rizzoli, Rene
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Maggi, Stefania
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Veronese, Nicola
a9a97f63-a828-45a3-bae0-68182c5a44fd
Shivappa, Nitin
ab7ce1dc-e4c3-4adc-9a45-cdd62acdfca0
Stubbs, Brendon
bccb7f03-83dc-4c03-82f7-58b89ce91bc5
Smith, Toby
8af789d2-e097-40af-9632-514501c3c2f1
Hebert, Jame R.
4dd954ef-c6f9-4114-b926-b13a6e39b378
Cooper, Cyrus
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Guglielmi, Giuseppe
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Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Rizzoli, Rene
e02c0d92-6da1-430c-a669-0c20e94a850a
Maggi, Stefania
57e7e62a-b7dd-4291-82e3-efc8c9a7e12a
Veronese, Nicola, Shivappa, Nitin, Stubbs, Brendon, Smith, Toby, Hebert, Jame R., Cooper, Cyrus, Guglielmi, Giuseppe, Reginster, Jean-Yves, Rizzoli, Rene and Maggi, Stefania
(2017)
The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative.
European Journal of Nutrition, .
(doi:10.1007/s00394-017-1589-6).
Abstract
Purpose:
To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database.
Methods:
A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs).
Results:
Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1).
Conclusions:
Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.
Text
DII KOA_0603
- Accepted Manuscript
More information
Accepted/In Press date: 22 November 2017
e-pub ahead of print date: 5 December 2017
Identifiers
Local EPrints ID: 416336
URI: http://eprints.soton.ac.uk/id/eprint/416336
ISSN: 1436-6207
PURE UUID: 8a5cb2bf-7602-40ae-86ff-d8b887c896a5
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Date deposited: 13 Dec 2017 17:30
Last modified: 18 Mar 2024 05:06
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Contributors
Author:
Nicola Veronese
Author:
Nitin Shivappa
Author:
Brendon Stubbs
Author:
Toby Smith
Author:
Jame R. Hebert
Author:
Giuseppe Guglielmi
Author:
Jean-Yves Reginster
Author:
Rene Rizzoli
Author:
Stefania Maggi
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