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The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative

The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative
The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative
Purpose: To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database. Methods: A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1). Conclusions: Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.
1436-6207
1-8
Veronese, Nicola
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Shivappa, Nitin
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Stubbs, Brendon
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Smith, Toby
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Hebert, Jame R.
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Cooper, Cyrus
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Guglielmi, Giuseppe
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Reginster, Jean-Yves
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Rizzoli, Rene
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Maggi, Stefania
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Veronese, Nicola
a9a97f63-a828-45a3-bae0-68182c5a44fd
Shivappa, Nitin
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Stubbs, Brendon
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Smith, Toby
8af789d2-e097-40af-9632-514501c3c2f1
Hebert, Jame R.
4dd954ef-c6f9-4114-b926-b13a6e39b378
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Guglielmi, Giuseppe
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Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Rizzoli, Rene
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Maggi, Stefania
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Veronese, Nicola, Shivappa, Nitin, Stubbs, Brendon, Smith, Toby, Hebert, Jame R., Cooper, Cyrus, Guglielmi, Giuseppe, Reginster, Jean-Yves, Rizzoli, Rene and Maggi, Stefania (2017) The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative. European Journal of Nutrition, 1-8. (doi:10.1007/s00394-017-1589-6).

Record type: Article

Abstract

Purpose: To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database. Methods: A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1). Conclusions: Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.

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Accepted/In Press date: 22 November 2017
e-pub ahead of print date: 5 December 2017

Identifiers

Local EPrints ID: 416336
URI: http://eprints.soton.ac.uk/id/eprint/416336
ISSN: 1436-6207
PURE UUID: 8a5cb2bf-7602-40ae-86ff-d8b887c896a5
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 13 Dec 2017 17:30
Last modified: 26 Nov 2021 06:44

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Contributors

Author: Nicola Veronese
Author: Nitin Shivappa
Author: Brendon Stubbs
Author: Toby Smith
Author: Jame R. Hebert
Author: Cyrus Cooper ORCID iD
Author: Giuseppe Guglielmi
Author: Jean-Yves Reginster
Author: Rene Rizzoli
Author: Stefania Maggi

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