Augmentation of musculoskeletal regeneration: role for pluripotent stem cells
Augmentation of musculoskeletal regeneration: role for pluripotent stem cells
The rise in the incidence of musculoskeletal diseases is attributed to an increasing ageing population. The debilitating effects of musculoskeletal diseases, coupled with a lack of effective therapies, contribute to huge financial strains on healthcare systems. The focus of regenerative medicine has shifted to Pluripotent Stem Cells (PSCs), namely human Embryonic Stem Cells (hESCs) and human induced PSCs (hiPSCs), due to the limited success of adult stem-cell (ASC) based interventions. PSCs constitute a valuable cell source for musculoskeletal regeneration due to their capacity for unlimited self-renewal, ability to differentiate into all cell lineages of the three germ layers and perceived immunoprivileged characteristics. This review summarises methods for chondrogenic, osteogenic, myogenic and adipogenic differentiation of PSCs and their potential for therapeutic applications.
189-206
Jevons, Lauren A.
effb7a8b-c625-4c21-b390-ad3ab2677705
Houghton, Franchesca D.
53946041-127e-45a8-9edb-bf4b3c23005f
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
March 2018
Jevons, Lauren A.
effb7a8b-c625-4c21-b390-ad3ab2677705
Houghton, Franchesca D.
53946041-127e-45a8-9edb-bf4b3c23005f
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Jevons, Lauren A., Houghton, Franchesca D. and Tare, Rahul S.
(2018)
Augmentation of musculoskeletal regeneration: role for pluripotent stem cells.
Regenerative Medicine, 13 (2), .
(doi:10.2217/rme-2017-0113).
Abstract
The rise in the incidence of musculoskeletal diseases is attributed to an increasing ageing population. The debilitating effects of musculoskeletal diseases, coupled with a lack of effective therapies, contribute to huge financial strains on healthcare systems. The focus of regenerative medicine has shifted to Pluripotent Stem Cells (PSCs), namely human Embryonic Stem Cells (hESCs) and human induced PSCs (hiPSCs), due to the limited success of adult stem-cell (ASC) based interventions. PSCs constitute a valuable cell source for musculoskeletal regeneration due to their capacity for unlimited self-renewal, ability to differentiate into all cell lineages of the three germ layers and perceived immunoprivileged characteristics. This review summarises methods for chondrogenic, osteogenic, myogenic and adipogenic differentiation of PSCs and their potential for therapeutic applications.
Text
Accepted manuscript_Jevons et al
- Accepted Manuscript
Text
rme-2017-0113
- Version of Record
More information
Accepted/In Press date: 6 December 2017
e-pub ahead of print date: 20 March 2018
Published date: March 2018
Identifiers
Local EPrints ID: 416669
URI: http://eprints.soton.ac.uk/id/eprint/416669
ISSN: 1746-0751
PURE UUID: 5c584568-0cfd-4f35-b93f-3ee6a41dbfbe
Catalogue record
Date deposited: 04 Jan 2018 17:30
Last modified: 16 Mar 2024 06:03
Export record
Altmetrics
Contributors
Author:
Lauren A. Jevons
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
