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Augmentation of musculoskeletal regeneration: role for pluripotent stem cells

Augmentation of musculoskeletal regeneration: role for pluripotent stem cells
Augmentation of musculoskeletal regeneration: role for pluripotent stem cells
The rise in the incidence of musculoskeletal diseases is attributed to an increasing ageing population. The debilitating effects of musculoskeletal diseases, coupled with a lack of effective therapies, contribute to huge financial strains on healthcare systems. The focus of regenerative medicine has shifted to Pluripotent Stem Cells (PSCs), namely human Embryonic Stem Cells (hESCs) and human induced PSCs (hiPSCs), due to the limited success of adult stem-cell (ASC) based interventions. PSCs constitute a valuable cell source for musculoskeletal regeneration due to their capacity for unlimited self-renewal, ability to differentiate into all cell lineages of the three germ layers and perceived immunoprivileged characteristics. This review summarises methods for chondrogenic, osteogenic, myogenic and adipogenic differentiation of PSCs and their potential for therapeutic applications.
1746-0751
189-206
Jevons, Lauren A.
effb7a8b-c625-4c21-b390-ad3ab2677705
Houghton, Franchesca D.
53946041-127e-45a8-9edb-bf4b3c23005f
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Jevons, Lauren A.
effb7a8b-c625-4c21-b390-ad3ab2677705
Houghton, Franchesca D.
53946041-127e-45a8-9edb-bf4b3c23005f
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a

Jevons, Lauren A., Houghton, Franchesca D. and Tare, Rahul S. (2018) Augmentation of musculoskeletal regeneration: role for pluripotent stem cells. Regenerative Medicine, 13 (2), 189-206. (doi:10.2217/rme-2017-0113).

Record type: Article

Abstract

The rise in the incidence of musculoskeletal diseases is attributed to an increasing ageing population. The debilitating effects of musculoskeletal diseases, coupled with a lack of effective therapies, contribute to huge financial strains on healthcare systems. The focus of regenerative medicine has shifted to Pluripotent Stem Cells (PSCs), namely human Embryonic Stem Cells (hESCs) and human induced PSCs (hiPSCs), due to the limited success of adult stem-cell (ASC) based interventions. PSCs constitute a valuable cell source for musculoskeletal regeneration due to their capacity for unlimited self-renewal, ability to differentiate into all cell lineages of the three germ layers and perceived immunoprivileged characteristics. This review summarises methods for chondrogenic, osteogenic, myogenic and adipogenic differentiation of PSCs and their potential for therapeutic applications.

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More information

Accepted/In Press date: 6 December 2017
e-pub ahead of print date: 20 March 2018
Published date: March 2018

Identifiers

Local EPrints ID: 416669
URI: http://eprints.soton.ac.uk/id/eprint/416669
ISSN: 1746-0751
PURE UUID: 5c584568-0cfd-4f35-b93f-3ee6a41dbfbe
ORCID for Franchesca D. Houghton: ORCID iD orcid.org/0000-0002-5167-1694
ORCID for Rahul S. Tare: ORCID iD orcid.org/0000-0001-8274-8837

Catalogue record

Date deposited: 04 Jan 2018 17:30
Last modified: 22 Nov 2021 06:00

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Contributors

Author: Lauren A. Jevons
Author: Rahul S. Tare ORCID iD

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