The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The urgent need for a harmonized severity scoring system for acute allergic reactions

The urgent need for a harmonized severity scoring system for acute allergic reactions
The urgent need for a harmonized severity scoring system for acute allergic reactions
The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that works across the range of allergenic triggers and addresses the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data-driven method that is informed by clinical and patient experience and other stakeholders’ perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that is clinically meaningful and is useful for allergy healthcare professionals and researchers; and (ii) a three grade based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice.
0105-4538
1792-1800
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Rivas, Montserrat Fernandez
e98af60e-7ac4-431c-b0c1-18fa9fefa594
Beyer, Kirsten
9020c231-b5ed-4c6c-be7e-797db0f2ab1d
Cardona, Victoria
a0844f96-a8d4-454e-bbb4-93aedef5d737
Clark, Andrew
f1b648d1-9a6a-41be-9afe-2ccfc5389fad
Eller, Esben
10418365-ece6-4dd9-8229-f9e1e6efdaec
O’B Hourihane, Jonathan
2eafa124-e02c-40fb-bb82-5c4de55f7838
Jutel, Marek
f73510dd-80fa-4613-bffd-876a59d3ff5d
Sheikh, Aziz
48655796-f608-4bb4-b4d9-6f58f0a6b1cd
Agache, Ioana
5a821a60-9456-48af-914b-476caa540f8f
Allen, Katrina J.
1b75b2a8-551b-49af-8ab4-4f7b593eca98
Angier, Liz
55f391cc-bf3f-4772-a1df-0dae8e9c429d
Ballmer-Weber, Barbara
545f0925-62e6-4a04-acae-848d005850db
Bilo, Maria Beatrice
abe29f9f-0d1e-492e-92ca-92ce239b4fdb
Bindslev-Jensen, Carsten
7e943cb1-ec32-4b51-9509-c9ee42e70185
Camargo, Jr, Carlos A.
29098121-727a-468e-8213-b6ebbd86d1cd
Cianferoni, Antonella
93c5d15e-d960-4b22-ac71-4728ef4215c3
DunnGalvin, Audrey
cb3a7df5-feb4-414a-b528-459c52dd2a80
Eigenmann, Philippe A.
9147c893-4f0e-4725-b6c7-e716abd24849
Halken, Susanne
2d3b1100-70d1-46e1-8466-15990d478a9f
Hoffmann-Sommergruber, Karin
91f22190-5608-407b-bb3b-63742c1bf524
Lau, Susanne
66bbde71-a61f-42fa-8ddb-8a94edcb1017
Nilsson, Caroline
a71723a3-7e8e-4631-885b-ad7c4ce5d6fd
Poulson, Lars K.
8adfc606-6ece-4916-9016-0288a6770185
Rueff, Franziska
9ff88093-1df0-497d-a31f-d1fe14b0b1e1
Spergel, Jonathan
094d5a93-50ac-41dc-9e2f-c2a1b7a31fcb
Sturm, Gunter
015a8aed-b9e1-46ec-8774-b3f136440e67
Timmermans, Frans
b6bb2f65-cf2f-4497-abee-1a247cfec494
Torres, Maria J.
bb6465bc-da64-4955-a5cd-6001ea8ed6d2
Turner, Paul
0d31f6ef-daa1-4351-91ab-4282783271ee
van Ree, Ronald
f6c2aabb-0e67-4e24-b2ed-b9c30641aebc
Wickham, Magnus
23511f66-0a72-4bab-9fa9-81d9f7762007
Worm, Margitta
59406574-ce5f-4ca5-9319-7543c719cc5b
Mills, E.N. Clare
7c362ef7-830f-40ed-9b4b-108f58973d98
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Muraro, Antonella
c554bef5-502b-4540-a6f0-a3f7c37f0075
Rivas, Montserrat Fernandez
e98af60e-7ac4-431c-b0c1-18fa9fefa594
Beyer, Kirsten
9020c231-b5ed-4c6c-be7e-797db0f2ab1d
Cardona, Victoria
a0844f96-a8d4-454e-bbb4-93aedef5d737
Clark, Andrew
f1b648d1-9a6a-41be-9afe-2ccfc5389fad
Eller, Esben
10418365-ece6-4dd9-8229-f9e1e6efdaec
O’B Hourihane, Jonathan
2eafa124-e02c-40fb-bb82-5c4de55f7838
Jutel, Marek
f73510dd-80fa-4613-bffd-876a59d3ff5d
Sheikh, Aziz
48655796-f608-4bb4-b4d9-6f58f0a6b1cd
Agache, Ioana
5a821a60-9456-48af-914b-476caa540f8f
Allen, Katrina J.
1b75b2a8-551b-49af-8ab4-4f7b593eca98
Angier, Liz
55f391cc-bf3f-4772-a1df-0dae8e9c429d
Ballmer-Weber, Barbara
545f0925-62e6-4a04-acae-848d005850db
Bilo, Maria Beatrice
abe29f9f-0d1e-492e-92ca-92ce239b4fdb
Bindslev-Jensen, Carsten
7e943cb1-ec32-4b51-9509-c9ee42e70185
Camargo, Jr, Carlos A.
29098121-727a-468e-8213-b6ebbd86d1cd
Cianferoni, Antonella
93c5d15e-d960-4b22-ac71-4728ef4215c3
DunnGalvin, Audrey
cb3a7df5-feb4-414a-b528-459c52dd2a80
Eigenmann, Philippe A.
9147c893-4f0e-4725-b6c7-e716abd24849
Halken, Susanne
2d3b1100-70d1-46e1-8466-15990d478a9f
Hoffmann-Sommergruber, Karin
91f22190-5608-407b-bb3b-63742c1bf524
Lau, Susanne
66bbde71-a61f-42fa-8ddb-8a94edcb1017
Nilsson, Caroline
a71723a3-7e8e-4631-885b-ad7c4ce5d6fd
Poulson, Lars K.
8adfc606-6ece-4916-9016-0288a6770185
Rueff, Franziska
9ff88093-1df0-497d-a31f-d1fe14b0b1e1
Spergel, Jonathan
094d5a93-50ac-41dc-9e2f-c2a1b7a31fcb
Sturm, Gunter
015a8aed-b9e1-46ec-8774-b3f136440e67
Timmermans, Frans
b6bb2f65-cf2f-4497-abee-1a247cfec494
Torres, Maria J.
bb6465bc-da64-4955-a5cd-6001ea8ed6d2
Turner, Paul
0d31f6ef-daa1-4351-91ab-4282783271ee
van Ree, Ronald
f6c2aabb-0e67-4e24-b2ed-b9c30641aebc
Wickham, Magnus
23511f66-0a72-4bab-9fa9-81d9f7762007
Worm, Margitta
59406574-ce5f-4ca5-9319-7543c719cc5b
Mills, E.N. Clare
7c362ef7-830f-40ed-9b4b-108f58973d98
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3

Muraro, Antonella, Rivas, Montserrat Fernandez, Beyer, Kirsten, Cardona, Victoria, Clark, Andrew, Eller, Esben, O’B Hourihane, Jonathan, Jutel, Marek, Sheikh, Aziz, Agache, Ioana, Allen, Katrina J., Angier, Liz, Ballmer-Weber, Barbara, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Camargo, Jr, Carlos A., Cianferoni, Antonella, DunnGalvin, Audrey, Eigenmann, Philippe A., Halken, Susanne, Hoffmann-Sommergruber, Karin, Lau, Susanne, Nilsson, Caroline, Poulson, Lars K., Rueff, Franziska, Spergel, Jonathan, Sturm, Gunter, Timmermans, Frans, Torres, Maria J., Turner, Paul, van Ree, Ronald, Wickham, Magnus, Worm, Margitta, Mills, E.N. Clare and Roberts, Graham (2018) The urgent need for a harmonized severity scoring system for acute allergic reactions. Allergy, 73 (3), 1792-1800. (doi:10.1111/all.13408).

Record type: Article

Abstract

The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that works across the range of allergenic triggers and addresses the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data-driven method that is informed by clinical and patient experience and other stakeholders’ perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that is clinically meaningful and is useful for allergy healthcare professionals and researchers; and (ii) a three grade based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice.

Text
Developing_and_validating_a_harmonised_severity_scoring_system_2017_09_16_FINAL_FOR_SUBMISSION_R1 - Accepted Manuscript
Download (134kB)
Text
Developing and validating a harmonised severity scoring system 2017 09 16 FINAL FOR SUBMISSION R1
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 28 December 2017
e-pub ahead of print date: 13 January 2018
Published date: September 2018

Identifiers

Local EPrints ID: 416705
URI: http://eprints.soton.ac.uk/id/eprint/416705
ISSN: 0105-4538
PURE UUID: 3bae1f80-ba23-4e8f-820f-ccb79eb2e734
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 05 Jan 2018 17:30
Last modified: 26 Nov 2021 05:46

Export record

Altmetrics

Contributors

Author: Antonella Muraro
Author: Montserrat Fernandez Rivas
Author: Kirsten Beyer
Author: Victoria Cardona
Author: Andrew Clark
Author: Esben Eller
Author: Jonathan O’B Hourihane
Author: Marek Jutel
Author: Aziz Sheikh
Author: Ioana Agache
Author: Katrina J. Allen
Author: Liz Angier
Author: Barbara Ballmer-Weber
Author: Maria Beatrice Bilo
Author: Carsten Bindslev-Jensen
Author: Carlos A. Camargo, Jr
Author: Antonella Cianferoni
Author: Audrey DunnGalvin
Author: Philippe A. Eigenmann
Author: Susanne Halken
Author: Karin Hoffmann-Sommergruber
Author: Susanne Lau
Author: Caroline Nilsson
Author: Lars K. Poulson
Author: Franziska Rueff
Author: Jonathan Spergel
Author: Gunter Sturm
Author: Frans Timmermans
Author: Maria J. Torres
Author: Paul Turner
Author: Ronald van Ree
Author: Magnus Wickham
Author: Margitta Worm
Author: E.N. Clare Mills
Author: Graham Roberts ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×