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Calcium and vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank cohort

Calcium and vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank cohort
Calcium and vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank cohort
We investigated associations between calcium/vitamin D supplementation and incident cardiovascular events/deaths in a UK population-based cohort. UK Biobank is a large prospective cohort comprising 502,637 men and women aged 40-69 years at recruitment. Supplementation with calcium/vitamin D was self-reported, and information on incident hospital admission (ICD-10) for ischaemic heart disease (IHD), myocardial infarction (MI) any cardiovascular event, and subsequent death, was obtained from linkage to national registers. Cox Proportional Hazards models were used to investigate longitudinal relationships between calcium/vitamin D supplementation and hospital admission for men/women, controlling for covariates. 475,255 participants (median age 58years, 55.8% women) had complete data on calcium/vitamin D supplementation. 33,437 participants reported taking calcium supplements; 19,089 vitamin D; 10,007 both. In crude and adjusted analyses, there were no associations between use of calcium supplements and risk of incident hospital admission with either IHD, MI or any cardiovascular event, or subsequent death. Thus, for example, in unadjusted models, the hazard ratio (HR) for admission with myocardial infarction was 0.97 (95%CI:0.79,1.20; p = 0.79) amongst women taking calcium supplementation. Corresponding HR for men: 1.16 (95%CI:0.92,1.46;p = 0.22). After full adjustment, HR(95%CI) were 0.82 (0.62,1.07), p = 0.14 amongst women and 1.12 (0.85,1.48), p = 0.41 amongst men. Adjusted HR(95%CI) for admission with IHD were 1.05 (0.92,1.19), p = 0.50 amongst women and 0.97 (0.82,1.15), p = 0.77 amongst men. Results were similar for any cardiovascular admission and for vitamin D and combination supplementation. There were no associations with death, and in women, further adjustment for HRT use did not alter the associations. In this very large prospective cohort, there was no evidence that use of calcium/vitamin D supplementation was associated with increased risk of hospital admission or death following ischaemic or non-ischaemic cardiovascular events.
0884-0431
803-811
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
D'Angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Paccou, Julien
29503b6f-033e-479e-a7ff-b43d229a7e0b
Curtis, Elizabeth M.
6e344d0a-3893-4dd5-88ca-4cad00558cce
Edwards, Mark
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Walker-Bone, Karen
ad7d1336-ed2c-4f39-ade5-da84eb412109
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
D'Angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Paccou, Julien
29503b6f-033e-479e-a7ff-b43d229a7e0b
Curtis, Elizabeth M.
6e344d0a-3893-4dd5-88ca-4cad00558cce
Edwards, Mark
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Walker-Bone, Karen
ad7d1336-ed2c-4f39-ade5-da84eb412109
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Harvey, Nicholas C., D'Angelo, Stefania, Paccou, Julien, Curtis, Elizabeth M., Edwards, Mark, Raisi-Estabragh, Zahra, Walker-Bone, Karen, Petersen, Steffen E. and Cooper, Cyrus (2018) Calcium and vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank cohort. Journal of Bone and Mineral Research, 33 (5), 803-811. (doi:10.1002/jbmr.3375).

Record type: Article

Abstract

We investigated associations between calcium/vitamin D supplementation and incident cardiovascular events/deaths in a UK population-based cohort. UK Biobank is a large prospective cohort comprising 502,637 men and women aged 40-69 years at recruitment. Supplementation with calcium/vitamin D was self-reported, and information on incident hospital admission (ICD-10) for ischaemic heart disease (IHD), myocardial infarction (MI) any cardiovascular event, and subsequent death, was obtained from linkage to national registers. Cox Proportional Hazards models were used to investigate longitudinal relationships between calcium/vitamin D supplementation and hospital admission for men/women, controlling for covariates. 475,255 participants (median age 58years, 55.8% women) had complete data on calcium/vitamin D supplementation. 33,437 participants reported taking calcium supplements; 19,089 vitamin D; 10,007 both. In crude and adjusted analyses, there were no associations between use of calcium supplements and risk of incident hospital admission with either IHD, MI or any cardiovascular event, or subsequent death. Thus, for example, in unadjusted models, the hazard ratio (HR) for admission with myocardial infarction was 0.97 (95%CI:0.79,1.20; p = 0.79) amongst women taking calcium supplementation. Corresponding HR for men: 1.16 (95%CI:0.92,1.46;p = 0.22). After full adjustment, HR(95%CI) were 0.82 (0.62,1.07), p = 0.14 amongst women and 1.12 (0.85,1.48), p = 0.41 amongst men. Adjusted HR(95%CI) for admission with IHD were 1.05 (0.92,1.19), p = 0.50 amongst women and 0.97 (0.82,1.15), p = 0.77 amongst men. Results were similar for any cardiovascular admission and for vitamin D and combination supplementation. There were no associations with death, and in women, further adjustment for HRT use did not alter the associations. In this very large prospective cohort, there was no evidence that use of calcium/vitamin D supplementation was associated with increased risk of hospital admission or death following ischaemic or non-ischaemic cardiovascular events.

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More information

Accepted/In Press date: 23 December 2017
e-pub ahead of print date: 4 January 2018
Published date: 1 May 2018

Identifiers

Local EPrints ID: 416885
URI: https://eprints.soton.ac.uk/id/eprint/416885
ISSN: 0884-0431
PURE UUID: 1e66afbb-c573-4804-ba61-70fc38947df5
ORCID for Stefania D'Angelo: ORCID iD orcid.org/0000-0002-7267-1837
ORCID for Karen Walker-Bone: ORCID iD orcid.org/0000-0002-5992-1459
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 12 Jan 2018 17:30
Last modified: 06 Jun 2018 13:00

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