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Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety – role in complicated grief

Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety – role in complicated grief
Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety – role in complicated grief
Objectives: complicated grief (CG) following bereavement significantly increases the risk for mood and anxiety disorders. The severity of grief reactions may be interactively influenced by temperamental and psychological factors such as behavioural inhibition (BI) and separation anxiety (SA) as well as biological factors. Given its central role in attachment and stress processing, a genetic variant in the oxytocin receptor (OXTR) gene was thus investigated in order to elucidate the direction of association as well as its interaction with BI and SA in the moderation of CG severity.

Methods: ninety-three patients with mood and anxiety disorders were evaluated for CG by means of the Inventory of Complicated Grief (ICG), for BI using the Retrospective Self-Report of Inhibition (RSRI), and for symptoms of SA during adulthood using the Adult Separation Anxiety Scale (ASA-27). All patients were genotyped for OXTR rs2254298.

Results: OXTR genotype interacted with BI and, on a trend-level, with adult SA, to increase CG. Specifically, higher levels on the RSRI and ASA-27 scales, respectively, were related to higher ICG scores in GG genotype carriers.

Conclusions: the present study for the first time suggests a gene-environment interaction effect of an OXTR gene variant with behavioural inhibition and possibly also symptoms of adult separation anxiety in the moderation of vulnerability for complicated grief.
Temperament, affective disorders, anxiety disorders, gene-environment, bereavement
1562-2975
1-9
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Schiele, Miriam A
3ed65c71-24c9-44ba-a32d-33d630901959
Costa, Barbara
9d0c48a4-5ddc-42df-9f38-81e52006bfdc
Domschke, Katharina
7c6913b2-7906-4a9e-b3ee-003437dce668
Abelli, Marianna
99a89c50-b896-422c-ba9c-e620f3d3865b
Martini, Claudia
7fd48a13-9cfc-4329-b3a3-304e882f68a2
Pini, Stefano
7a849c15-0faa-4853-acd5-ed7d0faf90d0
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Schiele, Miriam A
3ed65c71-24c9-44ba-a32d-33d630901959
Costa, Barbara
9d0c48a4-5ddc-42df-9f38-81e52006bfdc
Domschke, Katharina
7c6913b2-7906-4a9e-b3ee-003437dce668
Abelli, Marianna
99a89c50-b896-422c-ba9c-e620f3d3865b
Martini, Claudia
7fd48a13-9cfc-4329-b3a3-304e882f68a2
Pini, Stefano
7a849c15-0faa-4853-acd5-ed7d0faf90d0

Baldwin, David, Schiele, Miriam A, Costa, Barbara, Domschke, Katharina, Abelli, Marianna, Martini, Claudia and Pini, Stefano (2018) Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety – role in complicated grief. The World Journal of Biological Psychiatry, 1-9. (doi:10.1080/15622975.2018.1430374).

Record type: Article

Abstract

Objectives: complicated grief (CG) following bereavement significantly increases the risk for mood and anxiety disorders. The severity of grief reactions may be interactively influenced by temperamental and psychological factors such as behavioural inhibition (BI) and separation anxiety (SA) as well as biological factors. Given its central role in attachment and stress processing, a genetic variant in the oxytocin receptor (OXTR) gene was thus investigated in order to elucidate the direction of association as well as its interaction with BI and SA in the moderation of CG severity.

Methods: ninety-three patients with mood and anxiety disorders were evaluated for CG by means of the Inventory of Complicated Grief (ICG), for BI using the Retrospective Self-Report of Inhibition (RSRI), and for symptoms of SA during adulthood using the Adult Separation Anxiety Scale (ASA-27). All patients were genotyped for OXTR rs2254298.

Results: OXTR genotype interacted with BI and, on a trend-level, with adult SA, to increase CG. Specifically, higher levels on the RSRI and ASA-27 scales, respectively, were related to higher ICG scores in GG genotype carriers.

Conclusions: the present study for the first time suggests a gene-environment interaction effect of an OXTR gene variant with behavioural inhibition and possibly also symptoms of adult separation anxiety in the moderation of vulnerability for complicated grief.

Text Schiele_et_al_OXTR complicated grief_WJBP_accepted - Accepted Manuscript
Restricted to Repository staff only until 12 January 2019.
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Text Schiele-OXYT-grief - Version of Record
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More information

Accepted/In Press date: 12 January 2018
Published date: 5 February 2018
Keywords: Temperament, affective disorders, anxiety disorders, gene-environment, bereavement

Identifiers

Local EPrints ID: 417117
URI: https://eprints.soton.ac.uk/id/eprint/417117
ISSN: 1562-2975
PURE UUID: 8ccdb326-09af-41c7-946e-aa3dbcd781ba

Catalogue record

Date deposited: 19 Jan 2018 17:30
Last modified: 09 Mar 2018 17:31

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Contributors

Author: David Baldwin
Author: Miriam A Schiele
Author: Barbara Costa
Author: Katharina Domschke
Author: Marianna Abelli
Author: Claudia Martini
Author: Stefano Pini

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