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Acquisition, remission, and persistence of eczema, asthma, and rhinitis in children

Acquisition, remission, and persistence of eczema, asthma, and rhinitis in children
Acquisition, remission, and persistence of eczema, asthma, and rhinitis in children
Background Allergic sensitization is associated with eczema, asthma, and rhinitis. However, it is unknown whether and how allergic sensitization is associated over time with acquisition, remission, and persistence of these diseases and their comorbidity. Objective To gain a better understanding of factors including allergic sensitization transitions that influence the temporal pattern of asthma, eczema, and rhinitis and their comorbidity during childhood. Methods In the Isle of Wight birth cohort, information on allergic sensitization to common allergens was collected at ages 4, 10, and 18 years along with asthma, rhinitis, and eczema status determined by clinical diagnosis. Logistic regressions were used to estimate subsequent and concurrent odds ratios of diseases transition with allergic sensitization transition status as the main independent variable. Two transition periods were considered, 4 to 10 years of age and 10 to 18 years of age. Results The odds of new diagnosis of allergic disease (no‐yes) was increased among subjects with acquired or persistent allergic sensitization to common allergens compared to subjects with no sensitization (acquisition of sensitization odds ratio [OR]=3.22, P < .0001; persistence of sensitization, OR=6.33, P < .0001). The odds of remission of allergic diseases (yes‐no) was lower among subjects with acquired or sustained allergic sensitization (acquisition, OR=0.18, P = .0001; persistence, OR=0.085, P < .0001), compared to subjects not sensitized. Subjects with acquired or persistent allergic sensitization were also had higher odds for persistence of disease (yes‐yes) than subjects not sensitized (acquisition, OR=5.49, P = .0001; persistence, OR=11.79, P < .0001). Conclusion Transition of allergic sensitizations to common allergens is a prognostic factor for subsequent or concurrent transition of eczema, asthma, and rhinitis. Prevention or reduction in allergic sensitization has a potential to lead to remission of these conditions.
0954-7894
568-576
Zhang, Hongmei
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Kaushal, Akhilesh
a7742b05-148f-411e-bd3d-c2c29ecdcfef
Soto-Ramírez, Nelís
3526295b-e2ec-4cf3-bc74-088d10943f45
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Ewart, Susan
28667421-3cf7-43d7-b1c3-ca27564938f7
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Arshad, Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Kaushal, Akhilesh
a7742b05-148f-411e-bd3d-c2c29ecdcfef
Soto-Ramírez, Nelís
3526295b-e2ec-4cf3-bc74-088d10943f45
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Ewart, Susan
28667421-3cf7-43d7-b1c3-ca27564938f7
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Arshad, Hasan
917e246d-2e60-472f-8d30-94b01ef28958

Zhang, Hongmei, Kaushal, Akhilesh, Soto-Ramírez, Nelís, Ziyab, Ali H., Ewart, Susan, Holloway, John W., Karmaus, Wilfried and Arshad, Hasan (2018) Acquisition, remission, and persistence of eczema, asthma, and rhinitis in children. Clinical & Experimental Allergy, 48 (5), 568-576. (doi:10.1111/cea.13096).

Record type: Article

Abstract

Background Allergic sensitization is associated with eczema, asthma, and rhinitis. However, it is unknown whether and how allergic sensitization is associated over time with acquisition, remission, and persistence of these diseases and their comorbidity. Objective To gain a better understanding of factors including allergic sensitization transitions that influence the temporal pattern of asthma, eczema, and rhinitis and their comorbidity during childhood. Methods In the Isle of Wight birth cohort, information on allergic sensitization to common allergens was collected at ages 4, 10, and 18 years along with asthma, rhinitis, and eczema status determined by clinical diagnosis. Logistic regressions were used to estimate subsequent and concurrent odds ratios of diseases transition with allergic sensitization transition status as the main independent variable. Two transition periods were considered, 4 to 10 years of age and 10 to 18 years of age. Results The odds of new diagnosis of allergic disease (no‐yes) was increased among subjects with acquired or persistent allergic sensitization to common allergens compared to subjects with no sensitization (acquisition of sensitization odds ratio [OR]=3.22, P < .0001; persistence of sensitization, OR=6.33, P < .0001). The odds of remission of allergic diseases (yes‐no) was lower among subjects with acquired or sustained allergic sensitization (acquisition, OR=0.18, P = .0001; persistence, OR=0.085, P < .0001), compared to subjects not sensitized. Subjects with acquired or persistent allergic sensitization were also had higher odds for persistence of disease (yes‐yes) than subjects not sensitized (acquisition, OR=5.49, P = .0001; persistence, OR=11.79, P < .0001). Conclusion Transition of allergic sensitizations to common allergens is a prognostic factor for subsequent or concurrent transition of eczema, asthma, and rhinitis. Prevention or reduction in allergic sensitization has a potential to lead to remission of these conditions.

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Allergic disease atopy transition Submission Update rev1 Final - Accepted Manuscript
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Accepted/In Press date: 28 December 2017
e-pub ahead of print date: 19 January 2018
Published date: 1 May 2018

Identifiers

Local EPrints ID: 417303
URI: http://eprints.soton.ac.uk/id/eprint/417303
ISSN: 0954-7894
PURE UUID: 584f3573-6158-4e44-b054-93a97ee8e543
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 29 Jan 2018 17:30
Last modified: 18 Feb 2021 16:49

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Contributors

Author: Hongmei Zhang
Author: Akhilesh Kaushal
Author: Nelís Soto-Ramírez
Author: Ali H. Ziyab
Author: Susan Ewart
Author: Wilfried Karmaus
Author: Hasan Arshad

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