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Asymmetric assembling of iron oxide nanocubes for improving magnetic hyperthermia performance

Asymmetric assembling of iron oxide nanocubes for improving magnetic hyperthermia performance
Asymmetric assembling of iron oxide nanocubes for improving magnetic hyperthermia performance
Magnetic hyperthermia (MH) based on magnetic nanoparticles (MNPs) is a promising adjuvant therapy for cancer treatment. Particle clustering leading to complex magnetic interactions affects the heat generated by MNPs during MH. The heat efficiencies, theoretically predicted, are still poorly understood because of lack of the control of the fabrication of such clusters with defined geometries and thus their functionality. This study aims to correlate the heating efficiency under MH of individually coated iron oxide nanocubes (IONCs) vs. soft colloidal nanoclusters made of small groupings of nanocubes arranged in different geometries. The controlled clustering of alkyl stabilized IONCs is achieved here during the water transfer procedure by tuning the fraction of the amphiphilic copolymer, poly(styrene-co-maleic anhydride) cumene terminated, to the nanoparticle surface. It is found that increasing the polymer-to-nanoparticle surface ratio leads to the formation of increasingly large nanoclusters with defined geometries. When compared to the individual nanocubes, we show here that controlled grouping of nanoparticles—so-called “dimers” and “trimers” comprised of two and three nanocubes, respectively—increases 2 specific absorption rate (SAR) values, while conversely, forming centrosymmetric clusters having more than four nanocubes leads to lower SAR values. Magnetization measurements and Monte-Carlo based simulations support the observed SAR trend, and reveal the importance of the dipolar interaction effect and its dependence on the details of the particle arrangements within the different clusters. individual nanocubes, we show here that controlled grouping of nanoparticles—so-called “dimers” and “trimers” comprised of two and three nanocubes, respectively—increases
1936-0851
12121-12133
Niculaes, Dina
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Lak, Aidin
e2ab6aa5-92eb-4297-8f30-80b437b46d5f
Anyfantis, George C.
b60e6121-ad39-46da-9b9d-3ebcd08ed487
Marras, Sergio
0d08b359-2ed4-4220-9cb8-273cf3b0388d
Laslett, Oliver
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Avugadda, Sahitya K.
f8b41b15-c73d-4179-98d9-6b9ae30d3b8b
Cassani, Marco
b233d21c-44b2-4841-bf00-ae17f1437811
Serantes, David
ac7782c0-f298-4414-98c7-7b3ed4b13a9f
Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Chantrell, Roy W.
e302f8d2-4450-4d1e-a944-50f40e93e7db
Pellegrino, Teresa
cb728d7e-81f2-4ceb-a635-96f68e03b6db
Niculaes, Dina
584503ba-a8a1-47c2-bb8a-b2f58971085c
Lak, Aidin
e2ab6aa5-92eb-4297-8f30-80b437b46d5f
Anyfantis, George C.
b60e6121-ad39-46da-9b9d-3ebcd08ed487
Marras, Sergio
0d08b359-2ed4-4220-9cb8-273cf3b0388d
Laslett, Oliver
26a9ecdf-102d-41f1-8997-0a037fa087f0
Avugadda, Sahitya K.
f8b41b15-c73d-4179-98d9-6b9ae30d3b8b
Cassani, Marco
b233d21c-44b2-4841-bf00-ae17f1437811
Serantes, David
ac7782c0-f298-4414-98c7-7b3ed4b13a9f
Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Chantrell, Roy W.
e302f8d2-4450-4d1e-a944-50f40e93e7db
Pellegrino, Teresa
cb728d7e-81f2-4ceb-a635-96f68e03b6db

Niculaes, Dina, Lak, Aidin, Anyfantis, George C., Marras, Sergio, Laslett, Oliver, Avugadda, Sahitya K., Cassani, Marco, Serantes, David, Hovorka, Ondrej, Chantrell, Roy W. and Pellegrino, Teresa (2017) Asymmetric assembling of iron oxide nanocubes for improving magnetic hyperthermia performance. ACS Nano, 11 (12), 12121-12133. (doi:10.1021/acsnano.7b05182).

Record type: Article

Abstract

Magnetic hyperthermia (MH) based on magnetic nanoparticles (MNPs) is a promising adjuvant therapy for cancer treatment. Particle clustering leading to complex magnetic interactions affects the heat generated by MNPs during MH. The heat efficiencies, theoretically predicted, are still poorly understood because of lack of the control of the fabrication of such clusters with defined geometries and thus their functionality. This study aims to correlate the heating efficiency under MH of individually coated iron oxide nanocubes (IONCs) vs. soft colloidal nanoclusters made of small groupings of nanocubes arranged in different geometries. The controlled clustering of alkyl stabilized IONCs is achieved here during the water transfer procedure by tuning the fraction of the amphiphilic copolymer, poly(styrene-co-maleic anhydride) cumene terminated, to the nanoparticle surface. It is found that increasing the polymer-to-nanoparticle surface ratio leads to the formation of increasingly large nanoclusters with defined geometries. When compared to the individual nanocubes, we show here that controlled grouping of nanoparticles—so-called “dimers” and “trimers” comprised of two and three nanocubes, respectively—increases 2 specific absorption rate (SAR) values, while conversely, forming centrosymmetric clusters having more than four nanocubes leads to lower SAR values. Magnetization measurements and Monte-Carlo based simulations support the observed SAR trend, and reveal the importance of the dipolar interaction effect and its dependence on the details of the particle arrangements within the different clusters. individual nanocubes, we show here that controlled grouping of nanoparticles—so-called “dimers” and “trimers” comprised of two and three nanocubes, respectively—increases

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Niculaes et al-accepted-20171120 - Accepted Manuscript
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Accepted/In Press date: 20 November 2017
e-pub ahead of print date: 20 November 2017
Published date: 26 December 2017

Identifiers

Local EPrints ID: 417312
URI: http://eprints.soton.ac.uk/id/eprint/417312
ISSN: 1936-0851
PURE UUID: fcfcd52b-e419-4533-95e0-ffd423646a04
ORCID for Ondrej Hovorka: ORCID iD orcid.org/0000-0002-6707-4325

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Date deposited: 29 Jan 2018 17:30
Last modified: 17 Dec 2019 05:39

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Contributors

Author: Dina Niculaes
Author: Aidin Lak
Author: George C. Anyfantis
Author: Sergio Marras
Author: Oliver Laslett
Author: Sahitya K. Avugadda
Author: Marco Cassani
Author: David Serantes
Author: Ondrej Hovorka ORCID iD
Author: Roy W. Chantrell
Author: Teresa Pellegrino

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