Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study: an in vitro study
Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study: an in vitro study
The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis, and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi colonisation, persistence of infection, and recalcitrance towards antimicrobials. There is therefore a pressing need for the development of novel treatment strategies that are effective against NTHi biofilm-associated diseases. SurgihoneyROTM is a honey-based product that has been bioengineered to enable the slow release of H2O2, a reactive oxygen species to which H. influenzae is susceptible. Treatment of established NTHi biofilms with SurgihoneyROTM significantly reduced biofilm viability through enhanced H2O2 production, and was shown to be more effective than the conventional antibiotic co-amoxiclav.
Amoxicillin-Potassium Clavulanate Combination/pharmacology, Anti-Bacterial Agents/metabolism, Bioengineering, Biofilms/drug effects, Child, Preschool, Dose-Response Relationship, Drug, Haemophilus influenzae/drug effects, Honey, Humans, Hydrogen Peroxide/metabolism, Microbial Viability/drug effects
554-558
Newby, Rachel S
17ac3607-c2b3-4a97-9f62-dab4c2f310b2
Dryden, Matthew
a6c300f9-5c26-4884-980b-c098b0688ab1
Allan, Raymond N
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Salib, Rami J
d6fde1c1-5b5e-43f7-ae1c-42cce6a0c9fc
June 2018
Newby, Rachel S
17ac3607-c2b3-4a97-9f62-dab4c2f310b2
Dryden, Matthew
a6c300f9-5c26-4884-980b-c098b0688ab1
Allan, Raymond N
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Salib, Rami J
d6fde1c1-5b5e-43f7-ae1c-42cce6a0c9fc
Newby, Rachel S, Dryden, Matthew, Allan, Raymond N and Salib, Rami J
(2018)
Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study: an in vitro study.
Journal of Clinical Pathology, 71 (6), .
(doi:10.1136/jclinpath-2017-204901).
Abstract
The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis, and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi colonisation, persistence of infection, and recalcitrance towards antimicrobials. There is therefore a pressing need for the development of novel treatment strategies that are effective against NTHi biofilm-associated diseases. SurgihoneyROTM is a honey-based product that has been bioengineered to enable the slow release of H2O2, a reactive oxygen species to which H. influenzae is susceptible. Treatment of established NTHi biofilms with SurgihoneyROTM significantly reduced biofilm viability through enhanced H2O2 production, and was shown to be more effective than the conventional antibiotic co-amoxiclav.
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Accepted/In Press date: 29 January 2018
e-pub ahead of print date: 15 February 2018
Published date: June 2018
Additional Information:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Keywords:
Amoxicillin-Potassium Clavulanate Combination/pharmacology, Anti-Bacterial Agents/metabolism, Bioengineering, Biofilms/drug effects, Child, Preschool, Dose-Response Relationship, Drug, Haemophilus influenzae/drug effects, Honey, Humans, Hydrogen Peroxide/metabolism, Microbial Viability/drug effects
Identifiers
Local EPrints ID: 417507
URI: http://eprints.soton.ac.uk/id/eprint/417507
ISSN: 0021-9746
PURE UUID: 9f20785f-71bc-48c4-96e0-6ebb7ea07c71
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Date deposited: 01 Feb 2018 17:30
Last modified: 12 Aug 2025 04:01
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Author:
Rachel S Newby
Author:
Matthew Dryden
Author:
Raymond N Allan
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