Holroyd, Christopher, Parker, L.M., Bennett, S., Zarroug, J., Underhill, C., Davidson, B., Armstrong, Ray, Harvey, Nicholas, Dennison, Elaine, Cooper, Cyrus and Edwards, C. J. (2018) Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis. Clinical and Experimental Rheumatology.
Abstract
Objective: to describe real world experience of switching from originator TNF inhibitor Remicade (infliximab), to the biosimilar Inflectra (infliximab) in severe inflammatory arthritis.
Methods: from May 2015 patients receiving Remicade (infliximab) were switched to Inflectra (infliximab). We compared discontinuation rates due to inefficacy and adverse events (AEs) after switching to Inflectra (infliximab) with discontinuation rates whilst receiving Remicade (infliximab) in the year prior to the switch.
Results: 59 patients agreed to switch, with 51 (86%) continuing after a mean follow-up 362 days (12.1 months.)
Conclusion: safety and clinical efficacy of Inflectra (infliximab) appears similar to that of Remicade (infliximab).
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- Faculties (pre 2018 reorg) > Faculty of Medicine (pre 2018 reorg) > Human Development & Health (pre 2018 reorg)
Current Faculties > Faculty of Medicine > Human Development and Health > Human Development & Health (pre 2018 reorg)
Human Development and Health > Human Development & Health (pre 2018 reorg) - Current Faculties > Faculty of Medicine > Human Development and Health > MRC Lifecourse Epidemiology Unit
Human Development and Health > MRC Lifecourse Epidemiology Unit - Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Institute for Life Sciences (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg)
Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Medicine (pre 2018 reorg) > Human Development & Health (pre 2018 reorg) > Medical Research Council (pre 2018 reorg)
Current Faculties > Faculty of Medicine > Human Development and Health > Human Development & Health (pre 2018 reorg) > Medical Research Council (pre 2018 reorg)
Human Development and Health > Human Development & Health (pre 2018 reorg) > Medical Research Council (pre 2018 reorg)
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