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Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis

Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis
Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis
Objective: to describe real world experience of switching from originator TNF inhibitor Remicade (infliximab), to the biosimilar Inflectra (infliximab) in severe inflammatory arthritis.

Methods: from May 2015 patients receiving Remicade (infliximab) were switched to Inflectra (infliximab). We compared discontinuation rates due to inefficacy and adverse events (AEs) after switching to Inflectra (infliximab) with discontinuation rates whilst receiving Remicade (infliximab) in the year prior to the switch.

Results: 59 patients agreed to switch, with 51 (86%) continuing after a mean follow-up 362 days (12.1 months.)

Conclusion: safety and clinical efficacy of Inflectra (infliximab) appears similar to that of Remicade (infliximab).
0392-856X
Holroyd, Christopher
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Parker, L.M.
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Bennett, S.
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Zarroug, J.
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Underhill, C.
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Davidson, B.
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Armstrong, Ray
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Harvey, Nicholas
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Dennison, Elaine
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Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Edwards, C. J.
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Holroyd, Christopher
bd50c028-34f5-493c-86da-eeb5f7ea9e78
Parker, L.M.
a6341bf2-0ec9-4ec2-9517-d6238a6eb83d
Bennett, S.
8b90d240-340a-4235-9592-0f34c58cd499
Zarroug, J.
88edb601-cdb3-4584-90bd-8dce720ee422
Underhill, C.
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Davidson, B.
1a3f15c8-5e74-4551-9d18-6c41448b65af
Armstrong, Ray
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Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Edwards, C. J.
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Holroyd, Christopher, Parker, L.M., Bennett, S., Zarroug, J., Underhill, C., Davidson, B., Armstrong, Ray, Harvey, Nicholas, Dennison, Elaine, Cooper, Cyrus and Edwards, C. J. (2018) Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis. Clinical and Experimental Rheumatology.

Record type: Article

Abstract

Objective: to describe real world experience of switching from originator TNF inhibitor Remicade (infliximab), to the biosimilar Inflectra (infliximab) in severe inflammatory arthritis.

Methods: from May 2015 patients receiving Remicade (infliximab) were switched to Inflectra (infliximab). We compared discontinuation rates due to inefficacy and adverse events (AEs) after switching to Inflectra (infliximab) with discontinuation rates whilst receiving Remicade (infliximab) in the year prior to the switch.

Results: 59 patients agreed to switch, with 51 (86%) continuing after a mean follow-up 362 days (12.1 months.)

Conclusion: safety and clinical efficacy of Inflectra (infliximab) appears similar to that of Remicade (infliximab).

Text Switching to biosimilar infliximab- Journal of Rheumatology 2nd submission - Accepted Manuscript
Restricted to Repository staff only until 1 December 2018.
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More information

Accepted/In Press date: 1 December 2017
e-pub ahead of print date: 15 January 2018

Identifiers

Local EPrints ID: 417508
URI: https://eprints.soton.ac.uk/id/eprint/417508
ISSN: 0392-856X
PURE UUID: 1d12e52a-4373-444d-9dbc-a282bd817325
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 01 Feb 2018 17:30
Last modified: 27 Apr 2018 16:30

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Contributors

Author: Christopher Holroyd
Author: L.M. Parker
Author: S. Bennett
Author: J. Zarroug
Author: C. Underhill
Author: B. Davidson
Author: Ray Armstrong
Author: Nicholas Harvey
Author: Elaine Dennison
Author: Cyrus Cooper ORCID iD
Author: C. J. Edwards

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