Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis
Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis
Objective: to describe real world experience of switching from originator TNF inhibitor Remicade (infliximab), to the biosimilar Inflectra (infliximab) in severe inflammatory arthritis.
Methods: from May 2015 patients receiving Remicade (infliximab) were switched to Inflectra (infliximab). We compared discontinuation rates due to inefficacy and adverse events (AEs) after switching to Inflectra (infliximab) with discontinuation rates whilst receiving Remicade (infliximab) in the year prior to the switch.
Results: 59 patients agreed to switch, with 51 (86%) continuing after a mean follow-up 362 days (12.1 months.)
Conclusion: safety and clinical efficacy of Inflectra (infliximab) appears similar to that of Remicade (infliximab).
Holroyd, Christopher
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Parker, L.M.
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Bennett, S.
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Zarroug, J.
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Underhill, C.
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Davidson, B.
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Armstrong, Ray
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Harvey, Nicholas
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Dennison, Elaine
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Cooper, Cyrus
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Edwards, C. J.
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Holroyd, Christopher
bd50c028-34f5-493c-86da-eeb5f7ea9e78
Parker, L.M.
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Bennett, S.
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Zarroug, J.
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Underhill, C.
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Davidson, B.
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Armstrong, Ray
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Harvey, Nicholas
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Dennison, Elaine
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Cooper, Cyrus
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Edwards, C. J.
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Holroyd, Christopher, Parker, L.M., Bennett, S., Zarroug, J., Underhill, C., Davidson, B., Armstrong, Ray, Harvey, Nicholas, Dennison, Elaine, Cooper, Cyrus and Edwards, C. J.
(2018)
Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis.
Clinical and Experimental Rheumatology.
Abstract
Objective: to describe real world experience of switching from originator TNF inhibitor Remicade (infliximab), to the biosimilar Inflectra (infliximab) in severe inflammatory arthritis.
Methods: from May 2015 patients receiving Remicade (infliximab) were switched to Inflectra (infliximab). We compared discontinuation rates due to inefficacy and adverse events (AEs) after switching to Inflectra (infliximab) with discontinuation rates whilst receiving Remicade (infliximab) in the year prior to the switch.
Results: 59 patients agreed to switch, with 51 (86%) continuing after a mean follow-up 362 days (12.1 months.)
Conclusion: safety and clinical efficacy of Inflectra (infliximab) appears similar to that of Remicade (infliximab).
Text Switching to biosimilar infliximab- Journal of Rheumatology 2nd submission
- Accepted Manuscript
Restricted to Repository staff only until 1 December 2018.
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Accepted/In Press date: 1 December 2017
e-pub ahead of print date: 15 January 2018
Identifiers
Local EPrints ID: 417508
URI: https://eprints.soton.ac.uk/id/eprint/417508
ISSN: 0392-856X
PURE UUID: 1d12e52a-4373-444d-9dbc-a282bd817325
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Date deposited: 01 Feb 2018 17:30
Last modified: 27 Apr 2018 16:30
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Contributors
Author:
Christopher Holroyd
Author:
L.M. Parker
Author:
S. Bennett
Author:
J. Zarroug
Author:
C. Underhill
Author:
B. Davidson
Author:
Ray Armstrong
Author:
C. J. Edwards
University divisions
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