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Cord metabolic profiles in obese pregnant women: insights into offspring growth and body composition

Cord metabolic profiles in obese pregnant women: insights into offspring growth and body composition
Cord metabolic profiles in obese pregnant women: insights into offspring growth and body composition
Context:offspring exposed in utero to maternal obesity have an increased risk of later obesity; however, the underlying mechanisms remain unknown.

Objective: to assess the effect of an antenatal lifestyle intervention in obese women on the offspring’s cord blood metabolic profile and to examine associations of the cord blood metabolic profile with maternal clinical characteristics and offspring anthropometry at birth and age 6 months.

Design: randomized controlled trial and cohort study.

Setting: the UK Pregnancies Better Eating and Activity Trial.

Participants: three hundred forty-four mother-offspring pairs.

Intervention: antenatal behavioral lifestyle (diet and physical activity) intervention.

Main Outcome Measures: targeted cord blood metabolic profile, including candidate hormone and metabolomic analyses.

Results: the lifestyle intervention was not associated with change in the cord blood metabolic profile. Higher maternal glycemia, specifically fasting glucose at 28 weeks gestation, had a linear association with higher cord blood concentrations of lysophosphatidylcholines (LPCs) 16.1 (β = 0.65; 95% confidence interval: 0.03 to 0.10) and 18.1 (0.52; 0.02 to 0.80), independent of the lifestyle intervention. A principal component of cord blood phosphatidylcholines and LPCs was associated with infant z scores of birth weight (0.04; 0.02 to 0.07) and weight at age 6 months (0.05; 0.00 to 0.10). Cord blood insulin growth factor (IGF)-1 and adiponectin concentrations were positively associated with infant weight z score at birth and at 6 months.

Conclusions: concentrations of LPCs and IGF-1 in cord blood are related to infant weight. These findings support the hypothesis that susceptibility to childhood obesity may be programmed in utero, but further investigation is required to establish whether these associations are causally related.
0021-972X
346-355
Patel, Nashita
4fcc3251-f638-407d-8ca8-e1d1648df078
Hellmuth, Christian
442a9371-2b60-457b-a96d-4259a827f089
Uhl, Olaf
ce12dd38-6d39-4466-970f-41bf1c40907f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Briley, Annette
43bc174a-0d1b-48c3-a87a-a809de2e2544
Welsh, Paul
09de190a-183c-444a-aa04-4b57b4cc81b1
Pauupathy, Dharmintra
1de6054a-9004-408b-ba96-9818b8cb4d7c
Seed, Paul T.
d3eda3f4-0e4c-4c17-9efd-dc75b583e79a
Koletzko, Berthold
db2fdfe7-a417-4e6f-9681-62e3a81c71ac
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
UPBEAT Consortium
Patel, Nashita
4fcc3251-f638-407d-8ca8-e1d1648df078
Hellmuth, Christian
442a9371-2b60-457b-a96d-4259a827f089
Uhl, Olaf
ce12dd38-6d39-4466-970f-41bf1c40907f
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Briley, Annette
43bc174a-0d1b-48c3-a87a-a809de2e2544
Welsh, Paul
09de190a-183c-444a-aa04-4b57b4cc81b1
Pauupathy, Dharmintra
1de6054a-9004-408b-ba96-9818b8cb4d7c
Seed, Paul T.
d3eda3f4-0e4c-4c17-9efd-dc75b583e79a
Koletzko, Berthold
db2fdfe7-a417-4e6f-9681-62e3a81c71ac
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f

Patel, Nashita, Hellmuth, Christian, Uhl, Olaf, Godfrey, Keith, Briley, Annette, Welsh, Paul, Pauupathy, Dharmintra, Seed, Paul T., Koletzko, Berthold and Poston, Lucilla , UPBEAT Consortium (2018) Cord metabolic profiles in obese pregnant women: insights into offspring growth and body composition. Journal of Clinical Endocrinology & Metabolism, 103 (1), 346-355. (doi:10.1210/jc.2017-00876).

Record type: Article

Abstract

Context:offspring exposed in utero to maternal obesity have an increased risk of later obesity; however, the underlying mechanisms remain unknown.

Objective: to assess the effect of an antenatal lifestyle intervention in obese women on the offspring’s cord blood metabolic profile and to examine associations of the cord blood metabolic profile with maternal clinical characteristics and offspring anthropometry at birth and age 6 months.

Design: randomized controlled trial and cohort study.

Setting: the UK Pregnancies Better Eating and Activity Trial.

Participants: three hundred forty-four mother-offspring pairs.

Intervention: antenatal behavioral lifestyle (diet and physical activity) intervention.

Main Outcome Measures: targeted cord blood metabolic profile, including candidate hormone and metabolomic analyses.

Results: the lifestyle intervention was not associated with change in the cord blood metabolic profile. Higher maternal glycemia, specifically fasting glucose at 28 weeks gestation, had a linear association with higher cord blood concentrations of lysophosphatidylcholines (LPCs) 16.1 (β = 0.65; 95% confidence interval: 0.03 to 0.10) and 18.1 (0.52; 0.02 to 0.80), independent of the lifestyle intervention. A principal component of cord blood phosphatidylcholines and LPCs was associated with infant z scores of birth weight (0.04; 0.02 to 0.07) and weight at age 6 months (0.05; 0.00 to 0.10). Cord blood insulin growth factor (IGF)-1 and adiponectin concentrations were positively associated with infant weight z score at birth and at 6 months.

Conclusions: concentrations of LPCs and IGF-1 in cord blood are related to infant weight. These findings support the hypothesis that susceptibility to childhood obesity may be programmed in utero, but further investigation is required to establish whether these associations are causally related.

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More information

Accepted/In Press date: 3 November 2017
e-pub ahead of print date: 13 November 2017
Published date: January 2018

Identifiers

Local EPrints ID: 417549
URI: https://eprints.soton.ac.uk/id/eprint/417549
ISSN: 0021-972X
PURE UUID: 4c88e34f-047c-4244-884d-615bb3353f43
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 02 Feb 2018 17:30
Last modified: 02 Feb 2018 17:30

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Contributors

Author: Nashita Patel
Author: Christian Hellmuth
Author: Olaf Uhl
Author: Keith Godfrey ORCID iD
Author: Annette Briley
Author: Paul Welsh
Author: Dharmintra Pauupathy
Author: Paul T. Seed
Author: Berthold Koletzko
Author: Lucilla Poston

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