The influence of a high fat diet on bone and soft tissue formation in Matrix Gla Protein knockout mice
The influence of a high fat diet on bone and soft tissue formation in Matrix Gla Protein knockout mice
Studies suggest bone growth and development are influenced by maternal nutrition, during intrauterine and early postnatal life. This study assessed the role of MGP and a maternal high fat diet on vitamin K-dependent proteins’ gene expression and their impact on bone formation. Knockout (KO) offspring were smaller than wild type (WT) littermates, yet possessed the same volume of intrascapular brown adipose tissue. The total proportion of body fat was reduced, but only in animals on a control diet. Lung air volume was observed to be comparable in both KO and WT animals on the same diet. The degree of aortic calcification was reduced in KO animals maintained on a HF diet. KO females on the high fat diet showed reduced cortical bone volume and thickness in the femur and tibia. Gene expression levels of GGCX and VKOR were reduced in control fed KO animals suggesting a potential link between gene expression levels of MGP, GGCX, and VKOR and total volumes of bone, calcified soft tissue, and iBAT; with implications for modulation of body length and mass. Our results confirm the important role for vitamin K in bone and calcified soft tissue, but now extend this role to include iBAT.
MGP; bone; maternal; high fat; iBAT
1-14
Lanham, Stuart
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Cagampang, Felino
7cf57d52-4a65-4554-8306-ed65226bc50e
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
26 February 2018
Lanham, Stuart
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Cagampang, Felino
7cf57d52-4a65-4554-8306-ed65226bc50e
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Lanham, Stuart, Cagampang, Felino and Oreffo, Richard
(2018)
The influence of a high fat diet on bone and soft tissue formation in Matrix Gla Protein knockout mice.
Scientific Reports, 8 (1), , [3635].
(doi:10.1038/s41598-018-21650-0).
Abstract
Studies suggest bone growth and development are influenced by maternal nutrition, during intrauterine and early postnatal life. This study assessed the role of MGP and a maternal high fat diet on vitamin K-dependent proteins’ gene expression and their impact on bone formation. Knockout (KO) offspring were smaller than wild type (WT) littermates, yet possessed the same volume of intrascapular brown adipose tissue. The total proportion of body fat was reduced, but only in animals on a control diet. Lung air volume was observed to be comparable in both KO and WT animals on the same diet. The degree of aortic calcification was reduced in KO animals maintained on a HF diet. KO females on the high fat diet showed reduced cortical bone volume and thickness in the femur and tibia. Gene expression levels of GGCX and VKOR were reduced in control fed KO animals suggesting a potential link between gene expression levels of MGP, GGCX, and VKOR and total volumes of bone, calcified soft tissue, and iBAT; with implications for modulation of body length and mass. Our results confirm the important role for vitamin K in bone and calcified soft tissue, but now extend this role to include iBAT.
Text
Nutrients MGP KO
- Accepted Manuscript
Text
s41598-018-21650-0
- Version of Record
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Accepted/In Press date: 7 February 2018
e-pub ahead of print date: 26 February 2018
Published date: 26 February 2018
Keywords:
MGP; bone; maternal; high fat; iBAT
Identifiers
Local EPrints ID: 417606
URI: http://eprints.soton.ac.uk/id/eprint/417606
ISSN: 2045-2322
PURE UUID: 62e47882-7ec6-461d-aa39-dc644f72a726
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Date deposited: 07 Feb 2018 17:30
Last modified: 16 Mar 2024 06:12
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Author:
Stuart Lanham
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