Ta, Le Duc Huy, Yap, Gaik Chin, Tay, Carina Jing Xuan, Lim, A S M, Huang, C.H., Chu, C.W., De Sessions, P.F., Shek, Lynette P., Goh, Anne, Van Bever, Hugo, Teoh, Oon Hoe, Soh, J.Y., Thomas, Biju, Ramamurthy, M.B., Goh, Daniel Y.T., Lay, Christophe, Soh, S.E., Chan, Yiong, Saw, Seang-Mei, Kwek, Kenneth, Chong, Yap-Seng, Godfrey, Keith, Hibberd, Martin Lloyd and Lee, Bee Wah (2018) Establishment of the nasal microbiota in the first 18 months of life - Correlation with early onset rhinitis and wheezing. Journal of Allergy and Clinical Immunology, 142 (1), 86-95. (doi:10.1016/j.jaci.2018.01.032).
Abstract
Background: the dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and the susceptibility to childhood respiratory disorders. Objective: the aim of this case-control study was to monitor, evaluate and compare the development of the nasal microbiota of infants who developed rhinitis and wheeze in the first 18 months of life with those of healthy controls. Methods: anterior nasal swabs of 122 subjects belonging to the GUSTO birth cohort were collected longitudinally over seven time points in the first 18 months of life. The nasal microbiota signatures were analyzed using 16S rRNA multiplexed pair-end sequencing from three clinical groups (1) rhinitis alone (n=28), (2) rhinitis with concomitant wheeze (n=34) and (3) healthy controls (n=60). Results: the maturation of the nasal microbiome followed distinctive patterns in infants from both rhinitis groups compared to controls. Bacterial diversity increased over the period of 18 months of life in control infants, whilst infants with rhinitis showed a decreasing trend (p<0.05). An increase in abundance of Oxalobacteraceae family (Proteobacteria phylum) and Aerococcaceae family (Firmicutes phylum) was associated with rhinitis and concomitant wheeze (adj p<0.01) whilst Corynebacteriaceae family (Actinobacteria phylum) and early colonization with Staphylococcaceae family (Firmicutes phylum) (3 weeks till 9 months) was associated with controls (adj p<0.05). The only difference between the rhinitis group and controls was a reduced abundance of Corynebacteriaceae family (adj p<0.05). Determinants of nasal microbiota succession included gender, mode of delivery, presence of siblings and infant care attendance. Conclusion: our results support the hypothesis that nasal microbiome is involved in the development of early onset rhinitis and wheeze in infants.
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