High sensitivity troponins in contemporary cardiology practice: are we turning a corner?
High sensitivity troponins in contemporary cardiology practice: are we turning a corner?
Introduction: Troponin is considered to be the gold standard biomarker for ruling out MI. There has been a drive to improve the diagnostic speed, and as such the high sensitivity cardiac troponin (hs-cTn) assays have been introduced into clinical practice and are now part of international guidelines. Their novel value in clinical practice more generally is becoming apparent.
Areas covered: In this review we will evaluate the evidence for the use of hs-cTn assays in clinical practice, the issues with the assay and how the hs-cTn can be utilized in the future as a biomarker of cardiovascular risk.
Expert commentary: The use of the hs-cTn assays as a ‘rule out’ test for MI is compelling, as a ‘rule in’ there are significant issues relating the specificity of the assay for MI. The future of the assay may lie in population screening and risk modeling.
49-57
Mariathas, Mark
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Olechowski, Bartosz
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Mahmoudi, Michael
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Curzen, Nicholas
70f3ea49-51b1-418f-8e56-8210aef1abf4
2018
Mariathas, Mark
e8dbbe0d-d303-41a4-a5a2-fa8900accfe6
Olechowski, Bartosz
b025b40b-f9fa-4b8e-8f57-310d47e57700
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Curzen, Nicholas
70f3ea49-51b1-418f-8e56-8210aef1abf4
Mariathas, Mark, Olechowski, Bartosz, Mahmoudi, Michael and Curzen, Nicholas
(2018)
High sensitivity troponins in contemporary cardiology practice: are we turning a corner?
Expert Review of Cardiovascular Therapy, 16 (1), .
(doi:10.1080/14779072.2018.1419063).
Abstract
Introduction: Troponin is considered to be the gold standard biomarker for ruling out MI. There has been a drive to improve the diagnostic speed, and as such the high sensitivity cardiac troponin (hs-cTn) assays have been introduced into clinical practice and are now part of international guidelines. Their novel value in clinical practice more generally is becoming apparent.
Areas covered: In this review we will evaluate the evidence for the use of hs-cTn assays in clinical practice, the issues with the assay and how the hs-cTn can be utilized in the future as a biomarker of cardiovascular risk.
Expert commentary: The use of the hs-cTn assays as a ‘rule out’ test for MI is compelling, as a ‘rule in’ there are significant issues relating the specificity of the assay for MI. The future of the assay may lie in population screening and risk modeling.
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Accepted/In Press date: 15 December 2017
e-pub ahead of print date: 28 December 2017
Published date: 2018
Identifiers
Local EPrints ID: 417739
URI: http://eprints.soton.ac.uk/id/eprint/417739
ISSN: 1477-9072
PURE UUID: 0d9a54c9-bb09-4203-b28f-06669987a50e
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Date deposited: 12 Feb 2018 17:30
Last modified: 16 Mar 2024 06:09
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Author:
Mark Mariathas
Author:
Bartosz Olechowski
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