Placental fatty acid transfer
Placental fatty acid transfer
PURPOSE OF REVIEW: This review outlines recent advances in placental lipid transport in relation to maternal metabolic status and pregnancy outcome. A particular focus of this review will be on the way these findings may influence our understanding of placental transfer of the essential fatty acid docosahexaenoic acid (DHA) which is crucial for fetal neurodevelopment and of lipid transfer as a predisposing factor for childhood obesity.
RECENT FINDINGS: Placental metabolism may determine the quantity and composition of fatty acids delivered to the fetus. Maternal factors, such as obesity, appear to regulate placental lipid metabolism and may influence fatty acids delivery to the fetus. Although the role of placental metabolism is now recognized, new evidence also suggests important roles for nontraditional fatty acid transporters such as Mfsd2a which facilitates transfer of DHA.
SUMMARY: Placental lipid metabolism is likely to be a determinant of placental transfer of fatty acids to the fetus. Maternal conditions, such as obesity, have now been shown to regulate placental lipid metabolism and thus may influence fatty acid transfer and fetal development. However, it is not yet clear how regulation of placental lipid metabolism affects fatty acid delivery to the fetus and its long-term health.
REVIEW ARTICLE
78-82
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Wadsack, Christian
dd320713-7a3a-4049-85fe-dfe0193d838c
Desoye, Gernot
905d057f-c298-423a-9244-78b789ecdd68
March 2018
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Wadsack, Christian
dd320713-7a3a-4049-85fe-dfe0193d838c
Desoye, Gernot
905d057f-c298-423a-9244-78b789ecdd68
Lewis, Rohan M., Wadsack, Christian and Desoye, Gernot
(2018)
Placental fatty acid transfer.
Current Opinion in Clinical Nutrition and Metabolic Care, 21-2, .
(doi:10.1097/MCO.0000000000000443).
Abstract
PURPOSE OF REVIEW: This review outlines recent advances in placental lipid transport in relation to maternal metabolic status and pregnancy outcome. A particular focus of this review will be on the way these findings may influence our understanding of placental transfer of the essential fatty acid docosahexaenoic acid (DHA) which is crucial for fetal neurodevelopment and of lipid transfer as a predisposing factor for childhood obesity.
RECENT FINDINGS: Placental metabolism may determine the quantity and composition of fatty acids delivered to the fetus. Maternal factors, such as obesity, appear to regulate placental lipid metabolism and may influence fatty acids delivery to the fetus. Although the role of placental metabolism is now recognized, new evidence also suggests important roles for nontraditional fatty acid transporters such as Mfsd2a which facilitates transfer of DHA.
SUMMARY: Placental lipid metabolism is likely to be a determinant of placental transfer of fatty acids to the fetus. Maternal conditions, such as obesity, have now been shown to regulate placental lipid metabolism and thus may influence fatty acid transfer and fetal development. However, it is not yet clear how regulation of placental lipid metabolism affects fatty acid delivery to the fetus and its long-term health.
Text
Lewis - Current opinion review for 1st October - Final plus stars Revised
- Accepted Manuscript
More information
Accepted/In Press date: 22 November 2017
e-pub ahead of print date: 4 December 2017
Published date: March 2018
Keywords:
REVIEW ARTICLE
Identifiers
Local EPrints ID: 418378
URI: http://eprints.soton.ac.uk/id/eprint/418378
ISSN: 1363-1950
PURE UUID: 9a03e4aa-5aa7-49c1-805c-dbd420291614
Catalogue record
Date deposited: 05 Mar 2018 17:30
Last modified: 16 Mar 2024 06:02
Export record
Altmetrics
Contributors
Author:
Christian Wadsack
Author:
Gernot Desoye
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
