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Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze

Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze
Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze
Background: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. Aim: We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant’s risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort. Methodology: Interviewers collected information on demographics, lifestyle, birth data and allergic outcomes. Atopic sensitization was assessed through skin prick testing (SPT) to aeroallergens and food allergens. Results: A total of 135 (12.8%) children underwent phototherapy for neonatal hyperbilirubinemia. Infants who underwent phototherapy were of a significantly lower mean (SD) gestational age [37.5 (2.5) weeks] compared to those who did not [38.5 (1.2) weeks p<0.01]. A higher proportion of infants born by Caesarean section underwent phototherapy compared to those who were born vaginally (17.5% vs 10.7%, p < 0.01). There were no differences in prevalence of allergen sensitization, eczema, rhinitis and early onset wheeze with use of nebulizer in the first 5 years of life between subjects that underwent phototherapy and those that did not. There were also no associations between mean bilirubin peak levels within the phototherapy group with development of eczema, rhinitis and early onset wheeze in the first 5 years of life. Conclusions We found no evidence for a link between phototherapy for neonatal hyperbilirubinemia and childhood allergic outcomes in this prospective mother-offspring cohort.
28-34
Tham, Elizabeth H.
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Loo, Evelyn X.L.
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Goh, Anne
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Teoh, Oon Hoe
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Yap, Fabian
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Tan, Kok Hian
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Godfrey, Keith
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van Bever, Hugo
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Lee, Bee Wah
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Chong, Yap-Seng
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Shek, Lynette
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Tham, Elizabeth H.
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Loo, Evelyn X.L.
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Goh, Anne
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Teoh, Oon Hoe
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Yap, Fabian
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Tan, Kok Hian
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Godfrey, Keith
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van Bever, Hugo
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Lee, Bee Wah
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Chong, Yap-Seng
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Shek, Lynette
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Tham, Elizabeth H., Loo, Evelyn X.L., Goh, Anne, Teoh, Oon Hoe, Yap, Fabian, Tan, Kok Hian, Godfrey, Keith, van Bever, Hugo, Lee, Bee Wah, Chong, Yap-Seng and Shek, Lynette (2019) Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze. Pediatrics & Neonatology, 60 (1), 28-34. (doi:10.1016/j.pedneo.2018.03.004).

Record type: Article

Abstract

Background: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. Aim: We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant’s risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort. Methodology: Interviewers collected information on demographics, lifestyle, birth data and allergic outcomes. Atopic sensitization was assessed through skin prick testing (SPT) to aeroallergens and food allergens. Results: A total of 135 (12.8%) children underwent phototherapy for neonatal hyperbilirubinemia. Infants who underwent phototherapy were of a significantly lower mean (SD) gestational age [37.5 (2.5) weeks] compared to those who did not [38.5 (1.2) weeks p<0.01]. A higher proportion of infants born by Caesarean section underwent phototherapy compared to those who were born vaginally (17.5% vs 10.7%, p < 0.01). There were no differences in prevalence of allergen sensitization, eczema, rhinitis and early onset wheeze with use of nebulizer in the first 5 years of life between subjects that underwent phototherapy and those that did not. There were also no associations between mean bilirubin peak levels within the phototherapy group with development of eczema, rhinitis and early onset wheeze in the first 5 years of life. Conclusions We found no evidence for a link between phototherapy for neonatal hyperbilirubinemia and childhood allergic outcomes in this prospective mother-offspring cohort.

Text
Phototherapy Paper - Pediatrics Neonatology - English Edits revisions - Accepted Manuscript
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More information

Accepted/In Press date: 20 March 2018
e-pub ahead of print date: 24 March 2018
Published date: February 2019

Identifiers

Local EPrints ID: 418394
URI: http://eprints.soton.ac.uk/id/eprint/418394
PURE UUID: a2c5b42c-8adc-4c9c-ac1c-a529b916bb33
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 06 Mar 2018 17:30
Last modified: 10 Jan 2022 05:01

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Contributors

Author: Elizabeth H. Tham
Author: Evelyn X.L. Loo
Author: Anne Goh
Author: Oon Hoe Teoh
Author: Fabian Yap
Author: Kok Hian Tan
Author: Keith Godfrey ORCID iD
Author: Hugo van Bever
Author: Bee Wah Lee
Author: Yap-Seng Chong
Author: Lynette Shek

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