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Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures - a post hoc analysis of the SCOOP Study

Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures - a post hoc analysis of the SCOOP Study
Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures - a post hoc analysis of the SCOOP Study
The SCreening for Osteoporosis in Older women for the Prevention of fracture [SCOOP] study was a community-based screening intervention, in women aged 70 to 85 years in the UK. In the screening arm, licensed osteoporosis treatments were recommended in women identified to be at high risk of hip fracture using the FRAX risk assessment tool (including BMD measurement). In the control arm, standard care was provided. Screening led to a 28% reduction in hip fractures over 5 years. In this planned post hoc analysis, we wished to examine for interactions between screening effectiveness on fracture outcome (any, osteoporotic and hip fractures) on the one hand and baseline FRAX 10-year probability of hip fracture on the other. All analyses were conducted on an intention-to-treat basis, based on the group to which women were randomised, irrespective of whether screening was completed.

Of 12,483 eligible participants, 6,233 women were randomised to screening, with treatment recommended in 898 (14.4%). No evidence of an effect or interaction was observed for the outcomes of any fracture or osteoporotic fracture. In the screening arm, 54 fewer hip fractures were observed than in the control arm (164 versus 218, 2.6% vs 3.5%), and commensurate with treatment being targeted to those at highest hip fracture risk, the effect on hip fracture increased with baseline FRAX hip fracture probability (p = 0.021 for interaction); for example, at the 10th percentile of baseline FRAX hip probability (2.6%), there was no evidence that hip fractures were reduced (HR 0.93, 0.71 to 1.23) but at the 90th percentile (16.6%), there was a 33% reduction (HR 0.67, 0.53 to 0.84). Prior fracture and parental history of hip fracture positively influenced screening effectiveness on hip fracture risk.

We conclude that women at high risk of hip fracture based on FRAX probability are responsive to appropriate osteoporosis management.
0884-0431
McCloskey, Eugene
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Johansson, Helena
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Harvey, Nicholas
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Shepstone, Lee
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Lenaghan, Elizabeth
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Fordham, Ric
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Harvey, Ian
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Howe, Amanda
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Cooper, Cyrus
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Clarke, Shane
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Gittoes, Neil
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Heawood, Amanda
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Holland, Richard
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Marshall, Tarnya
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O'Neill, Terence W
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Peters, Tim J.
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Redmond, Niamh
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Torgerson, David J.
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Kanis, John A.
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McCloskey, Eugene
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Johansson, Helena
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Harvey, Nicholas
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Shepstone, Lee
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Lenaghan, Elizabeth
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Fordham, Ric
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Harvey, Ian
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Howe, Amanda
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Cooper, Cyrus
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Clarke, Shane
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Gittoes, Neil
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Heawood, Amanda
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Holland, Richard
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Marshall, Tarnya
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O'Neill, Terence W
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Peters, Tim J.
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Redmond, Niamh
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Torgerson, David J.
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Kanis, John A.
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McCloskey, Eugene, Johansson, Helena, Harvey, Nicholas, Shepstone, Lee, Lenaghan, Elizabeth, Fordham, Ric, Harvey, Ian, Howe, Amanda, Cooper, Cyrus, Clarke, Shane, Gittoes, Neil, Heawood, Amanda, Holland, Richard, Marshall, Tarnya, O'Neill, Terence W, Peters, Tim J., Redmond, Niamh, Torgerson, David J. and Kanis, John A. (2018) Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures - a post hoc analysis of the SCOOP Study. Journal of Bone and Mineral Research. (doi:10.1002/jbmr.3411).

Record type: Article

Abstract

The SCreening for Osteoporosis in Older women for the Prevention of fracture [SCOOP] study was a community-based screening intervention, in women aged 70 to 85 years in the UK. In the screening arm, licensed osteoporosis treatments were recommended in women identified to be at high risk of hip fracture using the FRAX risk assessment tool (including BMD measurement). In the control arm, standard care was provided. Screening led to a 28% reduction in hip fractures over 5 years. In this planned post hoc analysis, we wished to examine for interactions between screening effectiveness on fracture outcome (any, osteoporotic and hip fractures) on the one hand and baseline FRAX 10-year probability of hip fracture on the other. All analyses were conducted on an intention-to-treat basis, based on the group to which women were randomised, irrespective of whether screening was completed.

Of 12,483 eligible participants, 6,233 women were randomised to screening, with treatment recommended in 898 (14.4%). No evidence of an effect or interaction was observed for the outcomes of any fracture or osteoporotic fracture. In the screening arm, 54 fewer hip fractures were observed than in the control arm (164 versus 218, 2.6% vs 3.5%), and commensurate with treatment being targeted to those at highest hip fracture risk, the effect on hip fracture increased with baseline FRAX hip fracture probability (p = 0.021 for interaction); for example, at the 10th percentile of baseline FRAX hip probability (2.6%), there was no evidence that hip fractures were reduced (HR 0.93, 0.71 to 1.23) but at the 90th percentile (16.6%), there was a 33% reduction (HR 0.67, 0.53 to 0.84). Prior fracture and parental history of hip fracture positively influenced screening effectiveness on hip fracture risk.

We conclude that women at high risk of hip fracture based on FRAX probability are responsive to appropriate osteoporosis management.

Text
SCOOP FRAX Manuscript JBMR Submission Dec 2017(Revision Feb 2018) Clean - Accepted Manuscript
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Accepted/In Press date: 13 February 2018
e-pub ahead of print date: 26 February 2018

Identifiers

Local EPrints ID: 418534
URI: https://eprints.soton.ac.uk/id/eprint/418534
ISSN: 0884-0431
PURE UUID: 2042bf68-eabf-44b7-b68a-3e67b756727c
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 09 Mar 2018 17:31
Last modified: 10 Dec 2019 05:32

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Contributors

Author: Eugene McCloskey
Author: Helena Johansson
Author: Nicholas Harvey ORCID iD
Author: Lee Shepstone
Author: Elizabeth Lenaghan
Author: Ric Fordham
Author: Ian Harvey
Author: Amanda Howe
Author: Cyrus Cooper ORCID iD
Author: Shane Clarke
Author: Neil Gittoes
Author: Amanda Heawood
Author: Richard Holland
Author: Tarnya Marshall
Author: Terence W O'Neill
Author: Tim J. Peters
Author: Niamh Redmond
Author: David J. Torgerson
Author: John A. Kanis

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