Resolution of fatty liver and weight loss: independent associations with changes in serum lipids and apolipoproteins
Resolution of fatty liver and weight loss: independent associations with changes in serum lipids and apolipoproteins
Background and aims: it is uncertain whether resolution of fatty liver can improve cardiovascular disease risk factors, independently of changes in body mass index (BMI). Our aim was to test whether resolution of fatty liver is associated with improvements in components of the lipid profile, independently of changes in BMI, and to quantify and compare the magnitude of benefit of resolution of liver fat, and decreases in BMI on the lipid profile.
Methods: 36,195 subjects with fatty liver were studied. Persistence/resolution of fatty liver was determined by ultrasound at follow up (mean = 4.93 years). Total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoproteins were measured at baseline and follow up. Regression modelling was undertaken to test the independence of associations between change in fatty liver status or change in BMI, with any change in lipid profile concentrations between baseline and follow up.
Results: mean (SD) age was 36.3 ± 6.6 and 39.8 ± 8.7 years (men and women, respectively). Resolution of fatty liver occurred in 7,086, and persisted in 29,109 subjects. Mean ± SD weight change was −3.2 ± 4.3 (∼1 kg/m2 decrease in BMI) with resolution of, and +0.5 ± 3.5 kg with persistence of fatty liver, respectively. Both resolution of fatty liver and decrease in BMI were independently associated with improvements in all components of the lipid profile and there was a similar magnitude of benefit associated with resolution of fatty liver, or 1 kg/m2 decrease in BMI.
Conclusions: resolution of fatty liver improves the lipid profile, independently of weight loss.
47-53
Sung, Ki-Chul
53824b66-4481-4e72-a76c-b688fa6d2955
Lee, Mi-Yeon
427cc3cd-24ea-4350-bdf5-055b5a11983e
Lee, Jong-Young
2317122a-c6ce-4231-b989-612ebecee4db
Lee, Sung-Ho
41fcbc86-a9d3-4515-97c1-f13b212abc16
Kim, Jang-Young
dac1c7ad-008b-4ba8-a395-34d7bca2693a
Wild, Sarah H
b5e7bbcd-db78-4d22-a31e-3a7afc5a3f7a
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
May 2018
Sung, Ki-Chul
53824b66-4481-4e72-a76c-b688fa6d2955
Lee, Mi-Yeon
427cc3cd-24ea-4350-bdf5-055b5a11983e
Lee, Jong-Young
2317122a-c6ce-4231-b989-612ebecee4db
Lee, Sung-Ho
41fcbc86-a9d3-4515-97c1-f13b212abc16
Kim, Jang-Young
dac1c7ad-008b-4ba8-a395-34d7bca2693a
Wild, Sarah H
b5e7bbcd-db78-4d22-a31e-3a7afc5a3f7a
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Sung, Ki-Chul, Lee, Mi-Yeon, Lee, Jong-Young, Lee, Sung-Ho, Kim, Jang-Young, Wild, Sarah H and Byrne, Christopher
(2018)
Resolution of fatty liver and weight loss: independent associations with changes in serum lipids and apolipoproteins.
Atherosclerosis, 272, .
(doi:10.1016/j.atherosclerosis.2018.03.018).
Abstract
Background and aims: it is uncertain whether resolution of fatty liver can improve cardiovascular disease risk factors, independently of changes in body mass index (BMI). Our aim was to test whether resolution of fatty liver is associated with improvements in components of the lipid profile, independently of changes in BMI, and to quantify and compare the magnitude of benefit of resolution of liver fat, and decreases in BMI on the lipid profile.
Methods: 36,195 subjects with fatty liver were studied. Persistence/resolution of fatty liver was determined by ultrasound at follow up (mean = 4.93 years). Total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoproteins were measured at baseline and follow up. Regression modelling was undertaken to test the independence of associations between change in fatty liver status or change in BMI, with any change in lipid profile concentrations between baseline and follow up.
Results: mean (SD) age was 36.3 ± 6.6 and 39.8 ± 8.7 years (men and women, respectively). Resolution of fatty liver occurred in 7,086, and persisted in 29,109 subjects. Mean ± SD weight change was −3.2 ± 4.3 (∼1 kg/m2 decrease in BMI) with resolution of, and +0.5 ± 3.5 kg with persistence of fatty liver, respectively. Both resolution of fatty liver and decrease in BMI were independently associated with improvements in all components of the lipid profile and there was a similar magnitude of benefit associated with resolution of fatty liver, or 1 kg/m2 decrease in BMI.
Conclusions: resolution of fatty liver improves the lipid profile, independently of weight loss.
Text
ATH_fatty liver accepted manuscript_070318
- Accepted Manuscript
Text
R2 SUPP TABLE
- Accepted Manuscript
More information
Accepted/In Press date: 7 March 2018
e-pub ahead of print date: 8 March 2018
Published date: May 2018
Identifiers
Local EPrints ID: 418678
URI: http://eprints.soton.ac.uk/id/eprint/418678
ISSN: 0021-9150
PURE UUID: dc2933b5-d173-4878-934e-b91ae15240e1
Catalogue record
Date deposited: 16 Mar 2018 17:30
Last modified: 16 Mar 2024 06:20
Export record
Altmetrics
Contributors
Author:
Ki-Chul Sung
Author:
Mi-Yeon Lee
Author:
Jong-Young Lee
Author:
Sung-Ho Lee
Author:
Jang-Young Kim
Author:
Sarah H Wild
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics